胎母输血综合征的实验室检测与临床干预  

Laboratory testing and clinical intervention of fetomaternal hemorrhage

作　　者：台胜飞 于洋[1] TAI Sheng-fei;YU Yang(Department of Transfusion Medicine,the First Medical Center of Chinese PLA General Hospital,Beijing 100853,China)

机构地区：[1]解放军总医院第一医学中心输血医学科,北京100853

出　　处：《中国临床新医学》2022年第8期687-693,共7页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

摘　　要：胎母输血综合征(FMH)是一种妊娠期罕见疾病,可能会导致胎儿宫内窘迫、贫血,甚至死亡,但FMH发病隐匿,缺乏特异性,因此,选择适当的检测方法进行早期诊断并积极治疗具有重要的临床意义。该文将详细介绍常见的FMH筛查实验,如Rosette screen、Kleihauer-Betke酸洗脱实验、anti-D抗体及anti-HbF抗体的流式细胞术等。FMH治疗方案的选择需考虑胎龄和病情严重程度。出现大量胎母输血时,治疗以宫内输血为首选。提高临床医师对于FMH的认识,重视早期诊断和治疗,有助于保障母婴生命安全。Fetomaternal hemorrhage(FMH)is a rare disease during pregnancy,which may lead to fetal distress,anemia,and even death.However,the onset of FMH is insidious and lacks specificity.Therefore,it is of great clinical significance to select appropriate detection methods for early diagnosis and active treatment.This paper introduces the common FMH screening assays in detail,such as Rosette screen,Kleihauer-Betke acid-elution test,anti-D antibody and anti-HbF antibody flow cytometry.The choice of the treatment plans for FMH needs to consider the gestational age and the severity of the disease.When a large amount of FMH occurs,intrauterine blood transfusion is the first choice for treatment.Improving clinicians’awareness of FMH,and paying attention to early diagnosis and treatment of FMH will help to ensure the life safety of mothers and their infants.

关 键 词：胎母输血综合征 Rosette screen Kleihauer-Betke酸洗脱实验 流式细胞术 抗D人免疫球蛋白 宫内输血 

分 类 号：R457.1[医药卫生—治疗学]