机化性肺炎患者临床特征的回顾性研究  

A retrospective study of on clinical features of patients with organizing pneumonia

作　　者：徐玉菲 范晓云[1] 姜雪勤[1] 宁雅静[1] Xu Yufei;Fan Xiaoyun;Jiang Xueqin;Ning Yajing(Department of Geriatric Respiratory and Critical Care,the First Affiliated Hospital of Anhui Medical University,Hefei 230022,China)

机构地区：[1]安徽医科大学第一附属医院老年呼吸与危重症医学科,合肥230022

出　　处：《中国临床保健杂志》2022年第4期534-537,共4页Chinese Journal of Clinical Healthcare

基　　金：国家自然科学基金项目(U1803126)。

摘　　要：目的探讨机化性肺炎(OP)的临床特征以提高该病的诊治水平。方法回顾性分析安徽医科大学第一附属医院经病理证实的53例OP患者临床表现、实验室指标及影像学特点。结果53例OP患者中男性29例(54.72%),女性24例(45.28%),年龄分布在24~81岁,咳嗽(83.02%)、咳痰(79.25%)、发热(41.51%)和咯血(30.19%)为常见症状,实验室检查淋巴细胞百分比减低(58.49%)、白蛋白水平减低(83.02%)、C反应蛋白升高(78.72%),影像学斑片状高密度影(86.79%),结节影(49.06%)、支气管充气征(32.08%)、胸腔积液(32.08%)也较为常见,部分伴有纵隔淋巴结肿大、胸膜增厚等。41例患者口服糖皮质激素治疗,12例患者未予以糖皮质激素治疗。随访患者中多数患者好转或病情稳定,少部分患者病情反复或进展。结论机化性肺炎的临床表现、实验室检查及影像学均缺乏特异性,需结合组织病理及病史特点等进行确诊。该病对激素敏感,一般预后良好。Objective To investigate the clinical characteristics of organizing pneumonia(OP)to improve the diagnosis level of the disease.Methods The clinical manifestations,laboratory indicators and radiographic features of 53 pathologically confirmed OP patients in the First Affiliated Hospital of Anhui Medical University were retrospectively analyzed.Results Among the 53 OP patients,29 were male(54.72%)and 24 were female(45.28%),ranging from^(2)4 to 81 years old.The common symptoms were cough(83.02%),expectoration(79.25%),fever(41.51%)and hemoptysis(30.19%).The percentage of lymphocytes decreased(58.49%),albumin decreased(83.02%),and C-reactive protein increased(78.72%)in laboratory examination.Patchy high-density shadow(86.79%),nodular shadow(49.06%),air-bronchogram(32.08%),and pleural effusion(32.08%)were also common in imaging.Some of them were accompanied by mediastina lymphadenopathy and pleural thickening.Forty-one patients received oral glucocorticoid therapy,and 12 did not.most of the patients improved or their condition was stable,and a small part of the patients′condition repeated or progression.Conclusions The clinical manifestations,laboratory examination and radiographic features of organizing pneumonia are lack of specificity,so histopathology and history should be combined to confirm the diagnosis.The disease is sensitive to hormones with a good prognosis.

关 键 词：机化性肺炎 病理状态 体征和症状 实验室检查和诊断 回顾性研究 

分 类 号：R563.1[医药卫生—呼吸系统]