柴苓舒肝丸对CUMS模型大鼠的影响  

Effect of Chailing Shugan Pills on CUMS Model Rats

作　　者：杜希扬 张培会 汤晓[1] 彭善祥[1] 范天柱 孙兆祥[1] 公素琴[1] DU Xiyang;ZHANG Peihui;TANG Xiao;PENG Shanxiang;FAN Tianzhu;SUN Zhaoxiang;GONG Suqin(不详;Linyi Traditional Chinese Medicine Hospital,Linyi 276000,China)

机构地区：[1]临沂市中医医院,山东临沂276000

出　　处：《中外医学研究》2022年第22期155-159,共5页CHINESE AND FOREIGN MEDICAL RESEARCH

基　　金：山东省中医药科技项目(2020Q116)。

摘　　要：目的:探讨柴苓舒肝丸对慢性不可预见性温和应激(CUMS)模型大鼠的影响。方法:健康SPF级Wistar大鼠60只,所有大鼠适应性饲养1周,随机将其分为对照组、模型组、阳性药组及中药组,每组15只。对照组正常饲养,其余各组采用CUMS法制备大鼠抑郁模型,在此基础上,阳性药组及中药组分别采用盐酸氟西汀和柴苓舒肝丸悬浊液(无菌蒸馏水配置)灌胃。比较四组大鼠灌胃1、14、28、42、56 d的体重,比较四组大鼠灌胃1、2个月旷场、悬尾、强迫游泳、水迷宫实验结果。结果:灌胃14、28 d,模型组、阳性药组及中药组体重均低于对照组(P<0.01);灌胃42 d阳性药组及中药组体重均高于模型组(P<0.01),灌胃42、56 d,中药组体重显著高于阳性药组(P<0.05)。灌胃1个月,模型组、阳性药组、中药组中央区域活动时间及运动总距离均短于对照组,直立次数少于对照组(P<0.01),灌胃2个月,阳性药组及中药组中央区域活动时间及运动总距离均长于模型组,直立次数多于模型组(P<0.01),中药组中央区域活动时间及运动总距离均长于阳性药组,直立次数多于阳性药组(P<0.05)。灌胃1个月,模型组、阳性药组、中药组悬尾不动时间长于对照组(P<0.01),灌胃2个月,阳性药组及中药组悬尾不动时间短于模型组(P<0.01),中药组悬尾不动时间短于阳性药组(P<0.05)。灌胃1个月,模型组、阳性药组、中药组游泳不动时间均长于对照组(P<0.01),灌胃2个月,阳性药组及中药组游泳不动时间均短于模型组(P<0.01)。灌胃1个月,模型组、阳性药组、中药组模型组逃避潜伏期长于对照组,目标象限记忆时间短于对照组(P<0.01),灌胃2个月,阳性药组及中药组逃避潜伏期时间短于模型组,目标象限记忆时间长于模型组(P<0.01)。结论:柴苓舒肝丸可改善大鼠的体重和抑郁,功能性消化不良(functional dyspepsia,FD),具有明显的疏肝解郁的作用。Objective:To investigate the effect of Chailing Shugan Pills on chronic unpredictable mild stress(CUMS)model rats.Method:A total of 60 healthy SPF grade Wistar rats,all rats were fed adaptively for 1 week,and they were randomly divided into control group,model group,positive drug group and traditional Chinese medicine group,with 15 rats in each group.The control group was fed normally,and the depression models of rats in other groups were prepared by CUMS method.On this basis,the positive drug group and the traditional Chinese medicine group were gavaged with Fluoxetine Hydrochloride and Chailing Shugan Pills suspension(sterile distilled water configuration)respectively.The body weights of the four groups of rats were compared at 1,14,28,42 and 56 days of gavage,and the results of open field,suspended tail,forced swimming and water maze tests were compared at 1 and 2 months of gavage.Result:Gavage lasted for 14 and 28 days,the body weight of the model group,the positive drug group and the traditional Chinese medicine group were lower than that of the control group(P<0.01);the body weight of the positive drug group and the traditional Chinese medicine group were higher than that of the model group 42 days of gavage(P<0.01).The body weight of the traditional Chinese medicine group were significantly higher than that of the positive drug group 42 and 56 days of gavage(P<0.05).One month of gavage,the central area activity time and motion total distance of the model group,positive drug group and traditional Chinese medicine group were shorter than those of the control group,and the number of upright were less than that of the control group(P<0.01).Two months of gavage,the central area activity time and motion total distance of the positive drug group and traditional Chinese medicine group were longer than those of the model group,and the number of upright were more than that of the model group(P<0.01),the central area activity time and total distance in the traditional Chinese medicine group were longer than those in

关 键 词：慢性温和应激 柴苓舒肝丸 功能性消化不良 疏肝解郁 

分 类 号：R285.5[医药卫生—中药学]