心房颤动患者左心耳封堵术后抗栓治疗新进展  

New developments in antithrombotic therapy after left atrial appendage occlusion in patients with atrial fibrillation

作　　者：吴新宁[1] 史荣华[1] 刘腾飞 冯玉佳[1] Wu Xinning;Shi Ronghua;Liu Tengfei;Feng Yujia(Department of Cardiology,People’s Hospital of Rizhao,Rizhao 267827,China)

机构地区：[1]日照市人民医院心内科,267827

出　　处：《中国心血管杂志》2022年第4期393-397,共5页Chinese Journal of Cardiovascular Medicine

摘　　要：心房颤动(AF)是缺血性卒中和血栓栓塞事件的独立危险因素,显著增加其发病率和死亡率。长期口服抗凝药(OAC)是预防血栓栓塞的主要手段,但是有些患者存在极高出血风险或OAC禁忌证。众多研究证实,对OAC耐受性差或存在禁忌证的AF患者,左心耳封堵术(LAAO)可作为替代OAC的非药物疗法,效果不劣于OAC治疗。近年来LAAO发展迅速,然而,LAAO后抗栓策略尚无统一标准,器械相关血栓(DRT)也引起了越来越多的关注。本文复习最新相关文献,对LAAO术后抗栓最新进展作一综述。Atrial fibrillation is an independent risk factor for ischemic stroke and thromboembolic events,significantly increasing their morbidity and mortality.Long-term oral anticoagulants(OAC)are the mainstay of thromboembolism prevention,but some patients with extremely high bleeding risk or contraindications to OAC.Numerous studies have confirmed that left atrial appendage occlusion(LAAO)can be an alternative therapy to OAC in patients with atrial fibrillation who are poorly tolerant of OAC or have contraindications.LAAO has developed rapidly in recent years.However,the uniform standards for antithrombotic strategies are still lacking and the device-related thrombosis(DRT)has also attracted more and more attention.In this article,we review the latest literature and summarize the new developments in antithrombotic therapy after LAAO.

关 键 词：心房颤动 左心耳封堵 抗栓治疗 

分 类 号：R541.75[医药卫生—心血管疾病]