MAGiC序列在HIV相关神经认知障碍诊断中的应用价值  

Application value of MAGiC sequences in the diagnosis of HIV-related neurocognitive disorders

作　　者：罗杰棋 周昀 巢华 云永兴 王展 鲍晓慧 郭昂 郑广平[1] Luo Jieqi;Zhou Yun;Chao Hua;Yun Yongxing;Wang Zhan;Bao Xiaohui;Guo Ang;Zheng Guangping(Department of Radiology,Shenzhen Third People's Hospital,Guangdong Shenzhen 518112,China)

机构地区：[1]深圳市第三人民医院放射科,广东深圳518112

出　　处：《新发传染病电子杂志》2022年第3期55-59,共5页Electronic Journal of Emerging Infectious Diseases

摘　　要：目的应用MAGiC技术定量测量HIV感染者颅内T1值、T2值、PD值,探索MAGiC序列在HIV相关神经认知障碍诊断中的应用价值。方法回顾性分析2021年5-9月在深圳市第三人民医院行磁共振MAGiC技术检查HIV感染者38例。根据是否出现HIV相关神经认知障碍(HAND)分为两组(非HAND组23例,HAND组15例),另选18例无HIV感染者为正常对照组。应用MAGiC技术定量测量大脑左右侧半卵圆中心、侧脑室前后角、左右侧基底节区、胼胝体膝部、脑干和小脑的T1弛豫时间(ms)、T2弛豫时间(ms)和质子密度PD(pu)值。采用独立样本Kruskal-Wallis检验进行两两组间对比,并绘制ROC曲线。结果①HAND组各测量点的T1值均高于非HAND组和正常对照组,差异有统计学意义(P<0.05);②非HAND组和正常对照组各测量点T1值、T2值、PD值差异均无统计学意义(P>0.05);③T1值对区分HAND、非HAND的效能最好,以右侧基底节T1值曲线下面积0.897最大,其敏感度为1,特异度为0.725,P<0.001,最佳诊断阈值998.33ms。结论HAND患者颅内各部位T1值明显高于非HAND患者和无HIV感染者,通过定量测量T1值可以反映HIV感染者是否出现神经认知障碍,可以作为一种判断HAND新的辅助检查技术。Objective To quantitatively measure intracranial T1 value,T2 value and PD value of AIDS patients with MAGiC technology,and to explore the application value of MAGiC sequence in the diagnosis of HIV-related neurocognitive disorders.Method From May 2021 to September 2021,38 hiv-infected patients were examined by magnetic resonance MAGiC technology in Shenzhen Third People’s Hospital were retrospectively analyzed.According to the presence of HIV-associated neurocognitive disorder(HAND),the patients were divided into two groups(23 cases in the non-HAND group and 15 cases in the HAND group),and 18 cases without HIV infection were selected as the normal control group.T1-mapping(MS),T2-mapping(MS)and proton density PD(PU)values of both centrum semiovale,anterior horn of lateral ventricle,posterior horn of lateral ventricle,both basal ganglia,genu of corpus callosum,brainstem and ce-rebellum were quantitatively measured by MAGiC technique.The independent samples Kruskal-Wallis test was used for comparison between two groups,and the ROC curve was drawn.Result①The T1 value of each measuring point in the HAND group was higher than that in the non-HAND group and the normal control group,and the difference was statistically significant(P<0.05);②There were no significant differences in T1,T2 and PD values between the non-HAND group and the normal control group(P>0.05);③T1 is the most effective for distinguishing HAND from non-hand.The area under the curve of T1 value in the right basal ganglia was 0.897,the sensitivity was 1,the specificity was 0.725,P<0.001,and the optimal diagnostic threshold was 998.33ms.Conclusion The T1 value of each intracranial part of HAND patients is significantly higher than that of non-HAND patients and non-HIV-infected patients.Quantitative measurement of T1 value can reflect whether HIV-infected patients.

关 键 词：人类免疫缺陷病毒 认知功能障碍 磁共振 定量成像技术 

分 类 号：R512.91[医药卫生—内科学]