2%酮康唑乳膏联合盐酸多西环素在成年女性寻常痤疮治疗中的临床应用  

Clinical Effect of 2%Ketoconazole Cream Combined with Doxycycline Hydrochloride in the Treatment of Adult Female Acne

作　　者：宋万里 蒲新露 季天皓 孟亚东 SONG Wanli;PU Xinlu;JI Tianhao;MENG Yadong(Department of Dermatology,Chongming Branch,Xinhua Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 202150,China)

机构地区：[1]上海交通大学医学院附属新华医院崇明分院皮肤科,上海202150

出　　处：《中国美容医学》2022年第8期29-32,共4页Chinese Journal of Aesthetic Medicine

摘　　要：目的:探讨2%酮康唑乳膏联合盐酸多西环素治疗成年女性寻常痤疮的临床疗效。方法:选取2019年1月-2020年10月笔者医院收治的126例成年女性寻常痤疮患者为研究对象,采用随机数字表法分为对照组(63例)、研究组(63例),对照组采用盐酸多西环素治疗,研究组在对照组的基础上另给予2%酮康唑乳膏治疗,两组均持续治疗10周后观察效果。对比两组治疗前后临床症状评分、疗效、皮肤生理指标情况,统计两组药物安全性。结果:两组治疗后的临床症状评分均低于治疗前,且研究组评分低于对照组,差异均有统计学意义(均P<0.05)。研究组总有效率高于对照组(P<0.05)。两组治疗后的经皮水分丢失量均低于治疗前,且研究组低于对照组,差异均有统计学意义(均P<0.05);两组治疗后的表皮含水量均高于治疗前,研究组高于对照组,差异均有统计学意义(均P<0.05)。两组总不良反应发生率对比差异无统计学意义(P>0.05)。结论:采用2%酮康唑乳膏联合盐酸多西环素治疗成年女性寻常痤疮可明显改善临床症状,增强疗效,促进皮肤屏障恢复,且安全性良好。Objective To explore the clinical efficacy of 2%ketoconazole cream combined with doxycycline hydrochloride in the treatment of adult female acne.Methods 126 adult female patients with acne in our hospital were selected as the research subjects from January 2019 to October 2020,and they were divided into control group(63 cases)and study group(63 cases)using a random number table.The control group was treated with doxycycline hydrochloride,and the study group was treated with 2%ketoconazole cream on the basis of the control group.The effects of both groups were observed after 10 weeks of continuous treatment.The clinical symptom scores,efficacy,and skin physiological indicators of the two groups before and after treatment were compared,and the safety of the two groups of drugs was calculated.Results The total scores of clinical symptoms of the two groups after treatment were lower than before treatment,and the total scores of the study group were lower than control group,the difference was statistically significant(all P<0.05).The total effective rate of the study group was higher than control group(P<0.05).The transdermal water loss after treatment in the two groups was lower than before treatment,and the study group was lower than the control group,the difference was statistically significant(all P<0.05).The epidermal water content of the two groups after treatment was higher than before treatment,and the study group was higher than control group,and the differences were statistically significant(all P<0.05).There was no significant difference in the incidence of total adverse reactions between the two groups(P>0.05).Conclusion Using 2%ketoconazole cream combined with doxycycline hydrochloride to treat adult female acne can significantly improve the clinical symptoms,enhance the efficacy,promote the recovery of the skin barrier,and has good safety.

关 键 词：酮康唑乳膏 多西环素 寻常痤疮 疗效 皮肤生理功能 安全性 

分 类 号：R758.733[医药卫生—皮肤病学与性病学]