NOX/ROS-NF-κB信号通路与动脉粥样硬化关系的研究进展  

Research progress on the relationship between NOX/ROS-NF-κB siginaling pathway and atherosclerosis

作　　者：魏佳明 王子焱 刘婷 王建国 郭志华 WEI Jiaming;WANG Ziyan;LIU Ting;WANG Jianguo;GUO Zhihua(The First Clinical College of Chinese Medicine,Hunan University of Chinese Medicine,Hunan Province,Changsha410208,China;College of Chinese Medicine,Hunan University of Chinese Medicine,Hunan Province,Changsha410208,China)

机构地区：[1]湖南中医药大学第一中医临床学院,湖南长沙410208 [2]湖南中医药大学中医学院,湖南长沙410208

出　　处：《中国医药导报》2022年第24期48-51,共4页China Medical Herald

基　　金：湖南省自然科学基金项目(2021JJ30492);湖南省中医药科研计划项目(2021029);湖南省教育厅科学研究项目(20A384);湖南中医药大学中医学一流学科重点项目(2021ZYX14)。

摘　　要：动脉粥样硬化(AS)发病机制复杂,涉及通路众多,其中NOX/ROS-NF-κB信号通路在AS形成过程中具有重要作用,但相关机制尚待进一步明确。本文主要对NOX/ROS-NF-κB信号通路进行概述,并总结该通路与AS之间的关系,以期为后续研究提供参考。Atherosclerosis(AS)is a complex disease involving many pathways.The NOX/ROS-NF-κB siginaling pathway plays an important role in the formation of AS,but the mechanism needs to be further clarified.This paper mainly summarizes the NOX/ROS-NF-κB signaling pathway,and elaborates the progress of NOX/ROS-NF-κB signaling pathway in the prevention and treatment of AS,so as to provide reference for follow-up research.

关 键 词：动脉粥样硬化 NOX/ROS-NF-κB信号通路 发病机制 烟酰胺腺嘌呤二核苷酸磷酸氧化酶 活性氧 核转录因子-kappa B 

分 类 号：R593.22[医药卫生—内科学]