不同剂量帕瑞昔布钠对直肠癌手术患者免疫指标血清S100βNSE TNF-α及IL-1β水平的影响  

Effect of Different Doses of Parecoxib Sodium on Immune Indexes,Serum S100βNSE TNF-αand IL-1βLevels in Patients Undergoing Surgery for Rectal Cancer

作　　者：张龙飞[1] 廖兴志[1] 刘宇芳[1] 翁玲 陆海波 ZHANG Longfei;LIAO Xingzhi;LIU Yufang(Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army,Jiangsu Wuxi 214000,China)

机构地区：[1]中国人民解放军联勤保障部队第904医院麻醉科,江苏无锡214000

出　　处：《河北医学》2022年第8期1399-1403,共5页Hebei Medicine

基　　金：无锡市卫生计生委科研项目,(编号:T201825)。

摘　　要：目的:探究不同剂量帕瑞昔布钠对直肠癌手术患者免疫指标、S100钙结合蛋白β(S100β)、神经元特异性烯醇化酶(NSE)肿瘤坏死因子-α(TNF-α)白细胞介素-1β(IL-1β)的影响。方法:将2018年3月至2021年6月于我院行直肠癌手术患者80例纳入研究,简单随机分为大剂量、小剂量、对照组,分别有30例、30例、20例。对照组于麻醉前20min与氯化钠(0.9%),大剂量组予40mg帕瑞昔布钠,小剂量组予20mg帕瑞昔布钠。分析比较三组术前、术后12h、24h免疫指标、血清S100β、NSE、TNF-α及IL-1β水平。结果:大剂量组镇痛泵按压次数显著少于小剂量、对照组,小剂量显著少于对照组,差异有统计学意义(P<0.05);S100β、TNF-α、IL-1β主体内效应(F_(时点)、F_(交互))、主体间效应(F_(组间))比较,差异有统计学意义(P<0.05),NSE仅在F_(时点)比较上差异有统计学意义(P<0.05),而组间差异及分组与时间的交互作用均无统计学意义(P>0.05)。CD3^(+)、CD4^(+)主体内效应(F_(时点)、F_(交互))、主体间效应(F_(组间))比较,差异有统计学意义(P<0.05),CD8^(+)仅在F_(时点)比较上差异有统计学意义(P<0.05),而组间差异及分组与时间的交互作用均无统计学意义(P>0.05)。结论:帕瑞昔布钠可显著改善直肠癌手术患者免疫指标、血清S100β、NSE、TNF-α及IL-1β水平,使用30mg时效果更佳。Objective:To investigate the Effect of different doses of parecoxib sodium on immune indexes,serum S100β,NSE,TNF-αand IL-1βlevels in patients undergoing surgery for rectal cancer.Methods:A total of 80 patients who underwent rectal cancer surgery in our hospital from March 2018 to June 2021 were included in the study.They were simply randomly divided into high-dose,low-dose and control groups,with 30 cases,30 cases and 20 cases respectively.The control group was treated with sodium chloride(0.9%)20 minutes before anesthesia,the high-dose group was given 30 mg parecoxib sodium,and the low-dose group was given 10 mg parecoxib sodiumβ,NSE,TNF-αAnd IL-1β.Results:The number of analgesic pump presses was significantly less in the high-dose group than in the low-dose and control groups,and significantly less in the low-dose than in the control group,with statistically significant differences(P<0.05);the differences were statistically significant(P<0.05)for the comparison of intersubject effects(F_(time point),F_(interaction))and between-subject effects(F_(between groups))for S100β,TNF-α,IL-1β,and NSE only for the F_(time point)comparison was statistically significant(P<0.05),while the between-group differences and group-time-interaction effects were not statistically significant(P>0.05).The differences were statistically significant(P<0.05)for the comparison of CD3^(+)and CD4^(+)within-subject effects(F_(time point),F_(interaction))and between-subject effects(F_(between groups)),and statistically significant(P<0.05)for CD8^(+)only for the comparison of F_(time point),while neither the between-group differences nor the interaction between groups and time were statistically significant(P>0.05).Conclusion:Parecoxib sodium significantly improved immune markers,serum S100β,NSE,TNF-αand IL-1βlevels in patients undergoing surgery for rectal cancer,with better results when 30mg was used.

关 键 词：帕瑞昔布钠 直肠癌 免疫指标 血清S100β 炎症因子 

分 类 号：R614[医药卫生—麻醉学] R735.37[医药卫生—外科学]