帕金森病与炎症介质的相关性及中医药干预的研究进展  

Research Progress on Correlation Between Parkinson’s Disease and Inflammatory Mediators and Intervention by Traditional Chinese Medicine

作　　者：李彤 孙灵芝[2] 吴宏赟[2] LI Tong;SUN Lingzhi;WU Hongyun(Shandong University of Traditional Chinese Medicine,Jinan 250355,China;The Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250014,China)

机构地区：[1]山东中医药大学,山东济南250355 [2]山东中医药大学附属医院,山东济南250011

出　　处：《山东中医杂志》2022年第9期1032-1037,共6页Shandong Journal of Traditional Chinese Medicine

基　　金：山东省中医药科技发展计划项目(编号:2019-0170)。

摘　　要：帕金森病是较为常见的进展性神经系统疾病,学者们广泛认为黑质-纹状体多巴胺能通路变性是帕金森病的主要机制,帕金森病的生理病理过程有炎症介质的参与。白细胞介素(IL)、同型半胱氨酸(HCY)、肿瘤坏死因子α(TNF-α)、α1-抗糜蛋白酶、干扰素-γ(IFN-γ)等相关炎症介质逐渐成为帕金森病治疗的研究新方向。就帕金森病及相关炎症介质的国内外研究进展及中医药的干预作用进行综述。参考文献36篇。Parkinson’s disease(PD)is a common progressive neurological disease.Scholars usually hold that the degeneration of the substantia nigra-striatal dopaminergic pathway is the main mechanism of PD.The physiological and pathological process of PD involves various inflammatory mediators.Interleukin(IL),homocysteine(HCY),tumor necrosis factor-α(TNF-α),α1-antichymotrypsin(ACT),interferon-γ(IFN-γ)and other related inflammatory mediators have gradually become new directions for research in the treatment of PD.In this paper the research progress of PD and related inflammatory mediators in China and abroad and the intervention effect of traditional Chinese medicine were reviewed.Thirty-six papers are cited in the references.

关 键 词：帕金森病 炎症介质 白细胞介素 同型半胱氨酸 肿瘤坏死因子-Α α1抗糜蛋白酶 干扰素-Γ 中医药治疗 

分 类 号：R277.725[医药卫生—中医学]