β肾上腺素能受体信号通路调控心力衰竭心肌纤维化作用机制的研究进展  

Research progress on the mechanism of β-adrenergic receptor signaling pathway regulating myocardial fibrosis in heart failure

作　　者：王新婷 鲁成[2] 史天云 钟逸航 刘永明[1] WANG Xinting;LU Cheng;SHI Tianyun;ZHONG Yihang;LIU Yongming(Department of Cardiovascular Medicine,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai201203,China;Department of Cardiovascular Medicine,the Seventh People′s Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai201203,China)

机构地区：[1]上海中医药大学附属曙光医院心血管内科,上海201203 [2]上海中医药大学附属第七人民医院心血管内科,上海201203

出　　处：《中国当代医药》2022年第24期23-27,共5页China Modern Medicine

基　　金：国家自然科学基金资助项目(81973611);上海中医药大学“研究生创新培养”专向科研项目(Y201940)。

摘　　要：心肌纤维化与心力衰竭密切相关,心力衰竭的发展伴随着心肌纤维化的病理改变,心肌纤维化是指心肌组织结构中胶原的过度积聚,是不良心肌重构的主要表现,而心肌重构又可降低组织顺应性,损伤心脏功能,促进心律失常的发生,加速心力衰竭的进展。β肾上腺素能受体(βAR)信号通路异常是心力衰竭的重要特征,βAR在心肌的生理调节中起基础性作用,而βAR系统过度激活会促进衰竭心脏的纤维化进程,诱导成纤维细胞增殖、胶原分泌、迁移并向肌成纤维细胞表型转化。本研究将βAR信号通路在心力衰竭心肌纤维化中的作用以及β_(1)AR、β_(2)AR、β_(3)AR与心肌纤维化的关联进行阐述,为有效针对疾病进展的病理机制提供潜在治疗策略的开发。Myocardial fibrosis is closely related to heart failure.The development of heart failure is accompanied by pathological changes of myocardial fibrosis.Myocardial fibrosis refers to the excessive accumulation of collagen in myocardial tissue structure,which is the main manifestation of adverse myocardial remodeling.Myocardial remodeling can reduce tissue compliance,damage cardiac function,promote the occurrence of arrhythmia and accelerate the progress of heart failure.Abnormalβ-adrenergic receptor(βAR)signaling pathway is an important feature of heart failure.βAR plays a fundamental role in the physiological regulation of myocardium.Over activation ofβAR system can promote the fibrosis process of heart failure,induce fibroblast proliferation,collagen secretion,migration and transform into myofibroblast phenotype.In this paper,the role ofβAR signaling pathway in myocardial fibrosis of heart failure and the relationship betweenβ_(1)AR,β_(2)AR,β_(3)AR and myocardial fibrosis were discussed,so as to provide the development of potential therapeutic strategies for effective targeting at the pathological mechanism of disease progression.

关 键 词：心力衰竭 心肌纤维化 Β肾上腺素能受体 信号通路 

分 类 号：R541.3[医药卫生—心血管疾病]