从全身型幼年特发性关节炎到慢性关节型成人斯蒂尔病合并左膝关节多发滑膜囊肿1例  

From systemic juvenile idiopathic arthritis to chronic arthritis type of adult-onset Still’s disease with multiple synovial cysts in the left knee:a case report

作　　者：欧阳志明[1] 马剑达[1] 韦秀宁[1] 梁锦坚[1] 郑东辉[1] 戴冽[1] Ouyang Zhiming;Ma Jianda;Wei Xiuning;Liang Jinjian;Zheng Donghui;Dai Lie(Department of Rheumatology,Sun Yat-sen Memorial Hospital,Sun Yat-Sen University,Guangzhou 510120,Guangdong,China)

机构地区：[1]中山大学孙逸仙纪念医院风湿免疫科,广州510120

出　　处：《中国医学前沿杂志（电子版）》2022年第8期54-58,I0001,共6页Chinese Journal of the Frontiers of Medical Science(Electronic Version)

摘　　要：本文报道1例从全身型幼年特发性关节炎发展到成人斯蒂尔病,在糖皮质激素、传统改善病情抗风湿药及生物制剂和小分子靶向药治疗下仍出现双腕、髋及膝关节滑膜炎及骨质破坏,右侧股骨头缺血坏死,并且反复左膝关节肿胀伴活动受限,最后诊断腘窝多发滑膜囊肿。经托珠单抗联合甲氨蝶呤、来氟米特及甲泼尼龙积极控制基础疾病、关节腔抽液及倍他米松注射等治疗后病情控制,左膝肿胀缓解。We reported a case of systemic juvenile idiopathic arthritis developed into adult-onset Still’s disease.Synovitis and bone destruction in both wrists,hips and knees and ischemic necrosis of the right femoral head were developed with recurrent left knee swelling with limited mobility,and finally multiple synovial cysts in the popliteal fossa were diagnosed,despite treatment with glucocorticoids,traditional disease-modifying antirheumatic drugs and biologics and small-molecule targeted drugs.After the treatment of Tocilzumab combined with methotrexate,leflunomide and methylprednisolone,joint cavity aspiration and betamethasone injection,the disease was controlled and the swelling of the left knee was relieved.

关 键 词：全身型幼年特发性关节炎 成人斯蒂尔病 滑膜囊肿 

分 类 号：R593.2[医药卫生—内科学]