三项生化指标在小儿病毒性心肌炎诊断中的价值研究  

Value of Three Biochemical Indexes in Diagnosis of Viral Myocarditis in Children

作　　者：高盈竹 肖小兵[1] 黄鹏[1] 邓建荣[1] 阮豫才[1] 郭银霞 GAO Yingzhu;XIAO Xiaobing;HUANG Peng;DENG Jianrong;RUAN Yucai;GUO Yinxia(Department of Pediatrics,North Guangdong People's Hospital,Shaoguan Guangdong 512000,China)

机构地区：[1]粤北人民医院儿科,广东韶关512000

出　　处：《中国卫生标准管理》2022年第14期39-43,共5页China Health Standard Management

摘　　要：目的探究小儿病毒性心肌炎诊断中,N端脑钠肽前体(N-terminal pro-B-type natriuretic peptide,NT-proBNP)、肌酸激酶同工酶-MB(creatine kinase-MB,CK-MB)、心肌肌钙蛋白(cardiac troponin,cTnⅠ)的诊断效能。方法选择粤北人民医院2019年12月—2021年12月收治的25例病毒性心肌炎患儿作为研究对象,并设计为观察组。另选择同时期健康体检无病毒性心肌炎的25例儿童作为对照组。50例研究对象均接受NT-proBNP、CK-MB、cTnⅠ指标检测。比较分析两组儿童NT-proBNP、CK-MB、cTnⅠ指标检测结果及其相关诊断效能。结果在指标值方面,观察组儿童NT-proBNP、CK-MB、cTnⅠ指标值均明显高于对照组,差异有统计学意义(P<0.05)。在诊断结果方面,NT-proBNP诊断出阳性26例,阴性24例;CK-MB诊断出阳性26例,阴性24例;cTnⅠ诊断出阳性25例,阴性25例;联合诊断阳性26例,阴性24例。在诊断效能方面,NT-proBNP、CK-MB、cTnⅠ的准确度、特异度和敏感度差异无统计学意义(P>0.05);与联合诊断相比,联合诊断效能明显高于NT-proBNP、CK-MB、cTnⅠ,差异有统计学意义(P<0.05)。在相关性方面,NT-proBNP、CK-MB、cTnⅠ的阳性表达与患儿病毒性心肌炎呈正相关,差异有统计学意义(P<0.05)。结论在小儿病毒性心肌炎诊断中,NT-proBNP、CK-MB、cTnⅠ联合诊断的效能高,可成为临床诊断的重要依据,具有重要应用价值。Objective To explore the diagnostic efficacy of N-terminal pro-B-type natriuretic peptide(NT-proBNP),creatine kinase MB(CK-MB)and cardiac troponin(cTnⅠ)in the diagnosis of viral myocarditis in children.Methods 25 children with viral myocarditis treated in North Guangdong People’s Hospital from December 2019 to December 2021 were selected as the research object and designed as the observation group.Another 25 children without viral myocarditis were selected as the control group.All 50 subjects were tested by NT-proBNP,CKMB and cTnⅠ.The detection results of NT-proBNP,CK MB and cTnⅠand their related diagnostic efficacy were compared and analyzed between the two groups.Results In terms of index values,the index values of NT-proBNP,CK-MB and cTnⅠin the observation group were significantly higher than those in the control group(P<0.05).In terms of diagnostic results,NTproBNP was diagnosed as positive in 26 cases and negative in 24 cases;CK-MB diagnosis was positive in 26 cases and negative in 24 cases.cTnⅠdiagnosis was positive in 25 cases and negative in 25 cases;The combined diagnosis was positive in 26 cases and negative in 24 cases.In terms of diagnostic efficacy,there was no significant difference in the accuracy,specificity and sensitivity of NT-proBNP,CK MB and cTnⅠ(P>0.05).Compared with combined diagnosis,the efficacy of combined diagnosis was significantly higher than that of NTproBNP,CK-MB and cTnⅠ(P<0.05).In terms of correlation,the positive expressions of NT-proBNP,CK-MB and cTnⅠwere positively correlated with viral myocarditis in children(P<0.05).Conclusion In the diagnosis of viral myocarditis in children,the combined diagnosis of NT-proBNP,CK-MB and cTnⅠhas high efficiency.It can become an important basis for clinical diagnosis and has important application value.

关 键 词：小儿 病毒性心肌炎 心肌酶谱 诊断 相关性 价值 

分 类 号：R725[医药卫生—儿科]