骨痨汤对老年脊柱结核病灶清除术后患者胃肠功能的影响  

Effects of Gulao decoction on gastrointestinal function in elderly patients with spinal tuberculosis after lesion debridement

作　　者：王新刚[1] 卫建民[1] 杨俊松 王自立 冯万立[1] 夏斌[1] 吕会强 王想福[4] WANG Xingang;WEI Jianmin;YANG Junsong;WANG Zili;FENG Wanli;XIA Bin;LYU Huiqiang;WANG Xiangfu(Baoji Hospital of Traditional Chinese Medicine,Baoji 721001,China)

机构地区：[1]宝鸡市中医医院,陕西宝鸡721001 [2]西安市红会医院,陕西西安710054 [3]西安国际医学中心医院骨科医院,陕西西安710100 [4]甘肃省中医院,甘肃兰州730050

出　　处：《陕西中医》2022年第9期1234-1237,共4页Shaanxi Journal of Traditional Chinese Medicine

基　　金：陕西省中医药管理局科研项目(2021-ZZ-LC026)。

摘　　要：目的:探究骨痨汤对老年脊柱结核病灶清除术后患者胃肠功能的影响。方法:选取80例老年脊柱结核患者随机分为观察组和对照组,每组40例。对照组患者术前、术后予以乙胺丁醇、利福平等常规药物。观察组在对照组基础上术后给予骨痨汤。比较两组患者胃肠道状况(排便复常时间、排气复常时间、肠鸣音复常时间)、中医证候积分、血清炎症因子(IL-6、IL-10、TNF-α)水平、腰椎功能障碍指数(ODI)、疼痛数字评价量表(NRS)。比较两组治疗效果及并发症发生情况。结果:观察组患者排便复常时间、排气复常时间、肠鸣音复常时间均短于对照组(均P<0.05)。治疗前,两组患者腰背疼痛、盗汗、发热、疲倦评分比较,差异无统计学意义(均P>0.05)。与治疗前比较,治疗2周后两组患者腰背疼痛、盗汗、发热、疲倦评分均下降,且观察组各项评分均低于对照组,差异有统计学意义(均P<0.05)。治疗前,两组患者IL-6、IL-10、TNF-α水平及ODI评分、NRS评分比较,差异无统计学意义(均P>0.05)。与治疗前比较,治疗3周后两组患者IL-6、IL-10、TNF-α水平和ODI评分、NRS评分均下降,且观察组低于对照组,差异有统计学意义(均P<0.05)。观察组治疗总有效率为90.00%,高于对照组的65.00%;观察组患者总并发症发生率低于对照组,差异有统计学意义(P<0.05)。结论:骨痨汤治疗脊柱结核病灶清除术疗效较好,可改善脊柱结核病灶清除术后患者胃肠功能,调控血清炎症因子水平,且安全性较好。Objective:To explore effects of Gulao decoction treated for elderly patients with spinal tuberculosis after lesion debridement.Methods:80 elderly patients with spinal tuberculosis were randomly divided into observation group and control group,with 40 cases in each group.The control group were treated with ethambutol and rifampicin before and after surgery.The observation group was given Gulao decoction in addition to the control group.Gastrointestinal status(defecation recovery time,exhaust recovery time,bowel sound recovery time),TCM syndrome score,serum inflammatory factors(IL-6,IL-10,TNF-α),ODI score,NRS scale of the two groups were compared.The therapeutic effect and occurrence of the two groups were compared.Results:The time of normal defecation recovery,normal exhaust recovery and normal recovery of bowel sounds in the observation group were shorter than those in the control group(all P<0.05).Before treatment,there were no statistical differences in the scores of pain,night sweats,fever and tiredness between the two groups(all P>0.05).After two weeks of treatment,the scores of pain,night sweats,fever and tiredness in both groups were decreased compared with those before treatment,and the above scores were lower in the observation group than those in the control group(all P<0.05).There were no statistical differences in the levels of IL-6,IL-10,TNF-αand ODI score,NRS scale between the two groups before treatment(all P>0.05).The levels of serum IL-6,IL-10,TNF-αand ODI score,NRS scale in both groups were reduced after three weeks of treatment compared to before treatment,and the above indicators in the observation group were lower than those in the control group(all P<0.05).The effective rate of treatment 90.00%in the observation group,which was higher than 65.00%in the control group,difference statistically significant(P<0.05).The incidence rates of complications in the observation group were lower than that in the control group(P<0.05).Conclusion:Gulao decoction can improved postoperative gastrointestinal

关 键 词：脊柱结核 肝肾亏虚 骨痨汤 病灶清除术 胃肠功能 炎症因子 

分 类 号：R52[医药卫生—内科学]