风轮菜地上部分2个新的齐墩果烷型三萜皂苷  

Two New Oleanane-type Triterpenoid Saponins from Aerial Part of Clinopodium chinense

作　　者：徐明杰 伍一炜 赵迪 徐玉岩 潘巧岭 赵田甜 周伟松 袁银银 徐暾海[1] 朱寅荻 XU Ming-jie;WU Yi-wei;ZHAO Di;XU Yu-yan;PAN Qiao-ling;ZHAO Tian-tian;ZHOU Wei-song;YUAN Yin-yin;XU Tun-hai;ZHU Yin-di(School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing 100029,China;School of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou 325035,China)

机构地区：[1]北京中医药大学中药学院,北京100029 [2]温州医科大学药学院,浙江温州325035

出　　处：《中国现代中药》2022年第8期1447-1455,共9页Modern Chinese Medicine

基　　金：国家自然科学基金项目(81703689);温州市科学技术协会项目(2019KXCX-KT);温州市科研项目(Y20190197)。

摘　　要：目的:对风轮菜地上部分70%乙醇提取物的正丁醇萃取部位进行化学成分研究。方法:综合运用硅胶、十八烷基硅烷键合硅胶(ODS)、Sephadex LH-20柱色谱及半制备高效液相色谱等方法对风轮菜地上部分70%乙醇提取物的正丁醇萃取部位进行分离纯化,并利用理化性质和波谱学特征进行结构鉴定。结果:从风轮菜的正丁醇萃取物中分离得到11个化合物,分别鉴定为3β,16β,23,28-四羟基-齐墩果烷-11(12),13(18)-二烯-3-O-β-D-吡喃葡萄糖基-(1→2)-β-D-吡喃葡萄糖苷(1)、3β,16β,23,28-四羟基-齐墩果烷-11(12),13(18)-二烯-3-O-[β-D-吡喃葡萄糖基-(1→2)]-[β-D-吡喃葡萄糖基-(1→3)]-β-D-吡喃葡萄糖苷(2)、柴胡皂苷a (3)、异落叶松脂素(4)、梣树脂酚(5)、8-羟基-7′-表松脂醇(6)、三角叶凤毛菊木脂素A (7)、柳叶柴胡酚(8)、异秦皮啶(9)、4-羟基-3-甲氧基苯基-1-丙烷-1,2-二醇(10)和布卢竹柏醇A(11)。结论:化合物1和2为新化合物,分别命名为风轮菜皂苷F和风轮菜皂苷G,化合物4~11为首次从风轮菜中分离得到。Objective: To study the chemical constituents of the n-butanol extract from Clinopodium chinense(Benth.) O. Kuntze. Methods: The chemical constituents were isolated and purified by column chromatography with silica gel, Sephadex LH-20, and ODS and semi-preparative high performance liquid chromatography(HPLC). Their structures were identified via nuclear magnetic resonance(NMR), high-resolution electrospray ionization-mass spectrometry(HR-ESIMS), and chemical methods. Results: Eleven chemical constituents were isolated and purified from the n-butanol extract of C. chinense and identified as 3β, 16β, 23, 28-tetrahydroxy-olean-11(12), 13(18)-dien-3-O-β-D-glucopyranosyl-(1→2)-β-Dglucopyranoside(1), 3β, 16β, 23, 28-tetrahydroxy-olean-11(12), 13(18)-dien-3-O-[β-D-glucopyranosyl-(1→2)]-[β-Dglucopyranosyl-(1→3)]-β-D-glucopyranoside(2), saikosaponin a(3),(+)-isolariciresinol(4), fraxiresinol(5), 8-hydroxy-7′-epipinoresinol(6), deltoignan A(7), salicifoliol(8), isofraxidin(9), 4-hydroxyl-3-methoxyphenyl-1-propane-1, 2-diol(10),and blumenol A(11). Conclusion: Compounds 1 and 2 were new compounds named as clinoposaponin F and clinoposaponin G, respectively, and compounds 4-11 were isolated from the aerial part of C. chinense for the first time.

关 键 词：风轮菜 化学成分 三萜皂苷 木脂素 

分 类 号：R284[医药卫生—中药学]