甘草粉末粒度分布与其品质的相关性研究  

Correlation Between Particle Size Distribution and Quality of Glycyrrhizae Radix et Rhizoma Powder

作　　者：李锬 王升[1] 田壮 尚兴朴 李鹏英 吕朝耕 康传志 万修福 周利[1] 郭兰萍[1] 王瑞杉 LI Tan;WANG Sheng;TIAN Zhuang;SHANG Xing-pu;LI Peng-ying;LYU Chao-geng;KANG Chuan-zhi;WAN Xiu-fu;ZHOU Li;GUO Lan-ping;WANG Rui-shan(State Key Laboratory Breeding Base of Dao-di Herbs,National Resource Center for Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China;China National Traditional Chinese Medicine Co.,Ltd.,Beijing 102600,China)

机构地区：[1]中国中医科学院中药资源中心道地药材国家重点实验室培育基地,北京100700 [2]中国中药有限公司,北京102600

出　　处：《中国现代中药》2022年第8期1456-1462,共7页Modern Chinese Medicine

基　　金：国家自然科学基金项目(81603239,81891014);中央级公益性科研院所基本科研业务费专项(ZZXT202005,ZZ13-YQ-092,ZZXT201901,ZZ13-YQ-084);国家重点研发计划项目(2017YFC1700701,2017YFC1701405)。

摘　　要：目的:通过粉体粒度分析客观准确地表征甘草质量。方法:通过粒度分析仪测定甘草粉体的粒度分布,并分析了粒度分布特性与甘草有效成分含量的相关性。结果:甘草粉末粒度分布与甘草有效成分含量之间存在显著相关性,即50.00~200.00μm分布越少,500.00~1000.00μm及更高的粒径范围内分布越多,甘草质量越好。可见粉末粒径在50.00~200.00、500.00~1000.00μm的分布与甘草质量直接相关。结论:采用粒度分析仪检测甘草粉末粒度分布,进而表征甘草品质具有一定的可行性,为规范中药材质量评价体系提供了新的方法。Objective: To characterize the quality of Glycyrrhizae Radix et Rhizoma(GR) objectively and accurately by particle size distribution. Methods: The particle size distribution of GR powder was measured by a particle size analyzer,and its correlation with the content of active components was investigated. Results: The results showed that there was a significant correlation between the particle size distribution of GR powder and the content of its active components.Specifically, the distribution in the range of 50.00-200.00 μm had a negative correlation to the quality of GR;on the contrary,the distribution in the range of 500.00-1000.00 μm and above was in a positive correlation with the quality. Therefore, the distribution of particle size in the ranges of 50.00-200.00, 500.00-1000.00 μm were directly related to the quality of GR.Conclusion: It is feasible to characterize the quality of GR by the particle size distribution detected by a particle size analyzer. This study provides a new method for standardizing the quality evaluation system of Chinese medicinal materials.

关 键 词：甘草 激光衍射 粒度分布 药材品质 

分 类 号：R282[医药卫生—中药学]