植入综合征  

Engraftment syndrome

作　　者：刘四喜[1] 文飞球[1] Liu Sixi;Wen Feiqiu(Department of Hematology and Oncology,Shenzhen Children′s Hospital,Shenzhen 518038,China)

机构地区：[1]深圳市儿童医院血液肿瘤科,518038

出　　处：《中国小儿急救医学》2022年第8期573-576,共4页Chinese Pediatric Emergency Medicine

摘　　要：植入综合征是造血干细胞移植术后、中性粒细胞恢复过程中发生的一种临床综合征,主要临床表现为非感染性发热、皮疹、毛细血管渗漏和非心源性肺水肿。植入综合征与移植后多种早期并发症的临床表现类似,其诊断与鉴别诊断存在一定困难。典型的植入综合征具有自限性,激素治疗有效,但若不及时识别和处置,可进展为脑病及多器官功能衰竭。本文围绕植入综合征的病理生理机制、临床表现、诊断与鉴别诊断、危险因素、治疗及预后进行论述,以期为临床医生提供指导和借鉴。Engraftment syndrome(ES)is a clinical syndrome that occurs after hematopoietic stem cell transplantation and during the recovery process of neutrophils.The main clinical manifestations include non-infectious fever,rash,capillary leakage and non-cardiogenic pulmonary edema,which may be similar with many early complications after transplantation.Therefore,it is sometimes difficult to be diagnosed and differentiated among different kinds of complications.Typical ES is self-limiting and has good response to steroids.However,patients with ES may result in encephalopathy and multi-organ failure if it is untreated without notice.In this review,we discussed the pathophysiological mechanisms,clinical manifestations,diagnosis and differential diagnosis,risk factors,treatment and prognosis of ES,aiming to provide guidance and reference for clinicians.

关 键 词：植入综合征 造血干细胞移植 

分 类 号：R457.7[医药卫生—治疗学]