以畜禽疱疹病毒为载体的重组基因工程疫苗研究进展  

Progress on Recombinant Genetic Engineering Vaccines Using Herpesviruses of Livestock and Poultry as Vectors

作　　者：张璐 何慧芬 秦爱建 钱琨 ZHANG Lu;HE Hui-fen;QIN Ai-jian;QIAN Kun(Key Laboratory of Jiangsu Preventive Veterinary Medicine/Key Laboratory for Avian Preventive Medicine,Ministry of Education,Yangzhou University,Yangzhou,Jiangsu,225009,China;Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses,Yangzhou,Jiangsu 225009,China;Institute of Comparative Medicine,Yangzhou University,Yangzhou,Jiangsu 225009,China)

机构地区：[1]扬州大学教育部禽类预防医学重点实验室/江苏省动物预防医学重点实验室,江苏扬州225009 [2]江苏省动物重要疫病与人兽共患病防控协同创新中心,江苏扬州225009 [3]扬州大学比较医学研究院,江苏扬州225009

出　　处：《动物医学进展》2022年第8期88-93,共6页Progress In Veterinary Medicine

基　　金：国家自然科学基金项目(32072839);江苏省农业科技自主创新资金项目(CX(19)3008);江苏高校“青蓝工程”资助项目(苏教师函[2021]11号);江苏省优势学科项目(苏财教[2018]192号)。

摘　　要：畜禽疱疹病毒常作为表达外源基因的活病毒载体,用于构建重组基因工程疫苗。论文从重组基因工程疫苗的常见构建方法着手,分析比较了利用不同方法构建重组疫苗的优缺点,并阐述了不同类重组病毒活载体疫苗的特征、免疫保护效果等研究现状,为今后新型疫苗的研发和相关疾病的防控提供参考。Animal herpesviruses are often used as live vectors expressing foreign genes to construct recombinant genetic engineering vaccines.In this paper,we reviewed the advantages and disadvantages of using each method to construct recombinant vaccines,and described the characteristics of various types of live vector vaccines,the current research status and their immune protection effects and so on,which provides reference for the development of new vaccines and the prevention and control of related diseases in the future.

关 键 词：疱疹病毒 重组活载体疫苗 研究进展 

分 类 号：S852.659.1[农业科学—基础兽医学]