抗菌肽抗病毒作用机制和应用研究进展  

Progress on Antiviral Mechanisms and Applications of Antimicrobial Peptides

作　　者：刘双双 秦保亮[2] 朱春玲 赵娅娅 赵雪芹[1] 夏小静[1] 胡建和[1] 王丹辉 王磊[1] 安志兴[1] LIU Shuang-shuang;QIN Bao-liang;ZHU Chun-ling;ZHAO Ya-ya;ZHAO Xue-qin;XIA Xiao-jing;HU Jian-he;WANG Dan-hui;WANG Lei;AN Zhi-xing(Animal Science and Technology College,Henan Institute of Science and Technology,Xinxiang,Henan,453003,China;Xinxiang Animal Disease Prevention and Control Center,Xinxiang,Henan,453003,China;Animal Disease Prevention and Control Center,Qianguo County,Jilin Songyuan,Jilin,138000,China)

机构地区：[1]河南科技学院动物科技学院,河南新乡453003 [2]新乡市动物疫病预防控制中心,河南新乡453003 [3]吉林省松原市前郭县动物疫病预防控制中心,吉林松原138000

出　　处：《动物医学进展》2022年第9期100-104,共5页Progress In Veterinary Medicine

基　　金：国家重点研发计划项目(2021YFD1301200);国家自然科学基金面上项目(32172862);河南省优秀青年科学基金项目(222300420043);中原科技创新领军人才项目(224200510024);河南省高等学校青年骨干教师培养计划(2020GGJS162)。

摘　　要：抗菌肽是体内器官被多种病原体感染后率先发挥作用的免疫途径之一。大多数抗菌肽表现出广谱的抗菌活性,最近的一些研究已经开始阐明抗菌肽的抗病毒特性、以及在抗菌肽在炎性反应中的调节作用和趋化作用,如抗菌肽LL-37、防御素、乳铁蛋白等。论文基于近年来有关抗菌肽抗病毒病原体的研究资料,重点阐述了不同类别的抗菌肽的功效和作用机制,提供了抗菌肽成为新型抗病毒药物的潜在应用和治疗策略,为抗菌肽成为对抗新出现的传染性病毒的潜在药物提供理论依据。Antimicrobial peptides are one of the first immune pathways to play a role in the infection of various pathogens.Most antimicrobial peptides show a broad spectrum of antibacterial activity.Recent studies have begun to clarify the antiviral properties of antimicrobial peptides,as well as the regulatory and chemotactic effects of antimicrobial peptides in the inflammatory response,such as antimicrobial peptide LL-37,defensin,lactoferrin,etc.This paper based on the information about the research of antibacterial peptide antiviral pathogens in recent years,expounds the different categories of efficacy and mechanism of action of antimicrobial peptides,provides the potential application of antimicrobial peptides as new antiviral drugs and treatment strategies,for providing theoretical basis in the antimicrobial peptides as potential drugs against the emergence of new infectious virus pathogens.

关 键 词：抗菌肽 抗病毒 机制 

分 类 号：S852.4[农业科学—基础兽医学]