全麻体外循环手术中应用右美托咪定对患者心功能和认知功能的影响  

Effects of Dexmedetomidine on Cardiac Function and Cognitive Function in Patients with General Anesthesia and Cardiopulmonary Bypass Surgery

作　　者：王兵兵 王波 张铁柱 薛壹丹 赵玉宏 黑巧红 张瑜[5] Wang Bing-bing;Wang Bo;Zhang Tie-zhu;Xue Yi-dan;Zhao Yu-hong;Hei Qiao-hong;Zhang Yu(Department of Anesthesiology,Wuxi Mingci Cardiovascular Hospital,Wuxi 214086,Jiangsu Province,China;Department of Extracorporeal Circulation,Wuxi Mingci Cardiovascular Hospital,Wuxi 214086,Jiangsu Province,China;ICU,Wuxi Mingci Cardiovascular Hospital,Wuxi 214086,Jiangsu Province,China;Department of Anesthesiology,Xi'an High-tech Hospital,Xi'an 710000,Shaanxi Province,China;Department of Anesthesiology,Second Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang 710018,Shaanxi Province,China)

机构地区：[1]无锡明慈心血管病医院麻醉科,江苏无锡214086 [2]无锡明慈心血管病医院体外循环科,江苏无锡214086 [3]无锡明慈心血管病医院ICU,江苏无锡214086 [4]西安高新医院麻醉科,陕西西安710000 [5]陕西中医药大学第二附属医院麻醉科,陕西咸阳710018

出　　处：《中外医药研究》2022年第2期39-41,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

摘　　要：目的:探讨全麻体外循环手术中应用右美托咪定对患者心功能和认知功能的影响。方法:选取2020年5月2022年3月于无锡明慈心血管病医院接受全麻体外循环手术的80例患者作为研究对象,依据抽签法将其分为对照组与观察组,每组40例。对照组实施常规麻醉,观察组实施右美托咪定麻醉,对比两组认知功能、心功能、术后不良反应发生率。结果:观察组术后1 d、3 d及术后1周的认知功能评分均高于对照组,差异有统计学意义(P<0.05);观察组术后24 h、48 h、72 h及术后1周的心肌肌酸激酶同工酶、氨基末端脑钠肽、中心静脉压、左心射血分数均优于对照组,差异有统计学意义(P<0.05);观察组术后不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论:全麻体外循环手术中应用右美托咪定,对患者认知功能及心功能的影响相对较小,并可在一定程度上减少术后不良反应,促进患者恢复,值得推广。Objective:To investigate the effect of dexmedetomidine on cardiac function and cognitive function in patients undergoing general anesthesia and cardiopulmonary bypass surgery.Methods:A total of 80 patients who received general anesthesia and cardiopulmonary bypass surgery in Wuxi Mingci Cardiovascular Hospital from May 2020 to March 2022 were selected as the research subjects.According to the lottery method,they were divided into control group and observation group,40 cases in each group.The control group was given conventional anesthesia,and the observation group was given dexmedetomidine anesthesia.The cognitive function,cardiac function,and incidence of postoperative adverse reactions were compared between the two groups.Results:The cognitive function scores of the observation group at 1 day,3 days and 1 week after operation were higher than those in the control group,and the difference was statistically significant(P<0.05).The myocardial creatine kinase isoenzyme,amino-terminal brain natriuretic peptide,cardiac venous pressure and left ventricular ejection fraction in the observation group were better than those in the control group at 24 h,48 h,72 h and 1 week after operation,and the differences were statistically significant(P<0.05).The incidence of postoperative adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion:The application of dexmedetomidine in general anesthesia and cardiopulmonary bypass surgery has relatively little effect on patients'cognitive function and cardiac function,and can reduce postoperative adverse reactions to a certain extent and promote patients'recovery,which is worthy of promotion.

关 键 词：全麻体外循环手术 心功能 认知功能 右美托咪定 

分 类 号：R47[医药卫生—护理学]