紫朱软膏治疗非缺血型糖尿病足溃疡的临床疗效及对血清中Th1/Th2细胞的影响  

Clinical Effect of Zizhu Ointment on Non-ischemic Diabetic Foot Ulcer and Its Effect on Serum Th1/Th2 Cells

作　　者：黄仁燕 闫少庆[1] 杨晓[1] 王丽翔[1] 胡啸明[1] 柳国斌[1] Huang Renyan;Yan Shaoqing;Yang Xiao;Wang Lixiang;Hu Xiaoming;Liu Guobin(Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

机构地区：[1]上海中医药大学附属曙光医院,上海201203

出　　处：《世界科学技术-中医药现代化》2022年第4期1586-1592,共7页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：上海市浦东新区卫生健康委员会卫生计生科研项目(PW2020E-4):基于区域联动的糖尿病足中医防治方案的临床研究,负责人:柳国斌;国家自然科学基金委员会面上项目(81774310):基于“煨脓长肉”理论从Notch通路调节巨噬细胞角度探讨紫朱软膏影响糖尿病溃疡愈合的机制,负责人:柳国斌。

摘　　要：目的观察紫朱软膏治疗非缺血型糖尿病足溃疡的临床疗效观察及其对Th1/Th2细胞的影响。方法将符合纳入标准的104例非缺血型糖尿病足溃疡患者随机分为试验组和对照组,各52例。两组均根据《中国2型糖尿病防治指南》给予基础治疗,试验组局部溃疡采用中药紫朱软膏干预,对照组采用藻酸钙敷料干预,两组每天换药1次,连续治疗8周。治疗前后评估两组患者溃疡面积大小,并于治疗前后观察两组患者Th1/Th2细胞(Th1相关细胞因子TNF-α、IL-2、INF-γ;Th2相关细胞因子:IL-4、IL-5、IL-10)、肝肾功能。结果两组临床疗效比较,试验组整体疗效优于对照组,具有统计学差异(P<0.05)。两组患者血清中细胞因子水平治疗后比较,试验组在TNF-α、IL-2水平上低于对照组,具有统计学差异(P<0.05),试验组在IL-4、IL-10水平上高于对照组,具有统计学差异(P<0.05);血清中细胞因子水平治疗前后组内比较,两组均在TNF-α、IL-2、INF-γ水平上较治疗前降低,试验组在IL-4、IL-5、IL-10水平上较治疗前升高,对照组在IL-4、IL-5水平上较治疗前升高,均有统计学差异(P<0.05)。结论中药紫朱软膏能有效促进非缺血型糖尿病足溃疡愈合,可能通过调节Th1/Th2细胞分化,降低炎症反应实现。Objective To observe the clinical efficacy of Zizhu ointment in the treatment of non-ischemic diabetic foot ulcer and its effect on Th1/Th2 cells. Methods 104 patients with non-ischemic diabetic foot ulcer were randomly divided into experimental group and control group, 52 cases in each group. The experimental group was intervened with Zizhu ointment, and the control group was intervened with calcium alginate dressing. The dressing of the two groups was changed once a day for 8 weeks. The ulcer area of the two groups were evaluated before and after treatment, and the Th1/Th2 cells(Th1 related cytokines TNF-α, IL-2, INF-γ;Th2 related cytokines: IL-4, IL-5, IL-10) and liver and kidney function of the two groups were observed before and after treatment.Results Compared the clinical efficacy of the two groups, the overall efficacy of the experimental group was better than that of the control group, with statistical difference(P<0.05). After treatment, the levels of TNF-α and IL-2 in the experimental group were lower than those in the control group(P<0.05), and the levels of IL-4 and IL-10 in the experimental group were higher than those in the control group(P<0.05). Compared with before treatment, the levels of TNF-α, IL-2 and INF-γ in the two groups were lower than before treatment, the levels of IL-4, IL-5 and IL-10 in the experimental group were higher than before treatment, and the levels of IL-4 and IL-5 in the control group were higher than before treatment(P<0.05).Conclusion Zizhu ointment can effectively promote the healing of non-ischemic diabetic foot ulcer, which may be achieved by regulating the differentiation of Th1/Th2 cells.

关 键 词：紫朱软膏 非缺血型 糖尿病足溃疡 TH1/TH2细胞 临床疗效 

分 类 号：R285.6[医药卫生—中药学]