Chronicβ-Citronellol Inhalation Rescues Parvalbumin Expression Loss in Prefrontal Cortex of Chronic Restraint Stress Mice  

作　　者：Zhuang Qianqian Zhuang Siyue Gong Yanling Li Shengtian 庄倩倩;庄似玥;龚艳玲;李胜天(Bio-X Institutes,Key Laboratory for the Genetics of Development and Neuropsychiatric Disorders Ministry of Education,Shanghai Key Laboratory of Psychotic Disorders,Brain Science and Technology Research Center,Shanghai Jiao Tong University,Shanghai,200240,China)

机构地区：[1]Bio-X Institutes,Key Laboratory for the Genetics of Development and Neuropsychiatric Disorders Ministry of Education,Shanghai Key Laboratory of Psychotic Disorders,Brain Science and Technology Research Center,Shanghai Jiao Tong University,Shanghai,200240,China

出　　处：《Journal of Shanghai Jiaotong university(Science)》2022年第4期512-520,共9页上海交通大学学报（英文版）

基　　金：the National Natural Science Foundation of China(No.81871064);the Science and Technology Conmission of Shanghai Municipality(No.13DZ2260500);the Innovation Program of Shanghai Municipal Education Commission(No.2019-01-07-00-02-E00037)。

摘　　要：Considerable evidence has revealed that essential oils and their main constituents possess anti-depressant and anxiolytic properties.In the current study,we report the effect ofβ-citronellol,the main component of rose essential oil,on depressive-like and anxiety-like behaviors in chronic restraint stress(CRS)mice.We found that chronic inhalation ofβ-citronellol for 14 days could increase locomotor activity in the open field test,decrease the percentage of immobility duration in the forced swimming test,and increase open arms exploration in elevated plus-maze test in CRS mice.Western blot experiment shows that chronicβ-citronellol inhalation rescues parvalbumin(PV)expression loss in the prefrontal cortex(PFC)of CRS mice.Correlation analysis reveals a strong relationship between the PV expression in PFC and the percentage of sucrose preference of the mice.These findings indicate the relationships between the PV gene expression of PFC and the effects ofβ-citronellol inhalation.

关 键 词：chronic reastraint stress(CRS)model depression GABAergic neuron PARVALBUMIN prefrontal cortex(PFC) 

分 类 号：Q189[生物学—神经生物学]