Severe progression of autoimmune hepatitis in a young COVID-19 adult patient: A case report  

作　　者：Neeraj Kumar Sushant Satyapriya Shaik Mohammad Tahaseen Kunal Singh Abhyuday Kumar 

机构地区：[1]Department of Trauma&Emergency,AIIMS Patna,Bihar,India,801505 [2]Department of Anaesthesiology,AIIMS Patna,Bihar,India,801505 [3]Department of Medicine,AIIMS Patna,Bihar,India,801505

出　　处：《Journal of Acute Disease》2022年第4期161-164,共4页急性病杂志（英文版）

摘　　要：Rationale:The impact of COVID-19 in patients with autoimmune liver disease treated with immunosuppressive therapy has not been described so far.This case report describes the clinical course of a patient with autoimmune hepatitis(AIH)who developed COVID-19 and the features of cytokine syndrome leading to its deterioration in our intensive care unit.Patient’s Concern:A 28-year-old male presented with generalized anasarca for two weeks and chronic liver disease for 8 months.Diagnosis:AIH and Covid-19 with features of cytokine storm syndrome.Interventions:Intravenous furosemide,mannitol,syrup lactulose,steroids(prednisolone 40 mg),azathioprine 1 mg/kg body weight,rifaximin,vitamin K,and blood products.Outcomes:The patient had hepatic encephalopathy and AIH and died on the 10th day after admission despite ventilatory support,sustained low-efficiency hemodialysis,and resuscition.Lessons:The dramatic release of cytokines and the inflammatory‐immune responses not only alter the pathophysiology but also affects the onset and severity of disease progression in patients with AIH.

关 键 词：COVID-19 Autoimmune hepatitis Cytokine storm syndrome Immunosuppressant drugs Liver dysfunction 

分 类 号：R563.1[医药卫生—呼吸系统] R575[医药卫生—内科学]