抗抑郁药生态毒性效应研究进展  

Research progress on ecotoxicological effects of antidepressants

作　　者：牛慧侠 王晓峰(综述)[2] 楼晓明(审校)[2] NIU Huixia;WANG Xiaofeng;LOU Xiaoming(School of Medicine,Ningbo University,Ningbo,Zhejiang 315000,China;Zhejiang Provincial Center for Disease Control and Prevention,Hangzhou,Zhejiang 310051,China)

机构地区：[1]宁波大学医学院,浙江宁波315000 [2]浙江省疾病预防控制中心,浙江杭州310051

出　　处：《预防医学》2022年第9期902-905,913,共5页CHINA PREVENTIVE MEDICINE JOURNAL

摘　　要：近年来抗抑郁药的消耗量日益增长,越来越多的抗抑郁药及其代谢产物进入水体和土壤环境,对常年生活在这种环境里的动物产生毒性危害,进而可能通过食物链的传递进入人体,带来健康隐患。本文收集2005—2021年国内外发表的关于环境中抗抑郁药污染及其毒性效应的研究文献,主要对抗抑郁药的生物蓄积、急性毒性、生殖与发育毒性、代谢影响和生物行为改变等毒性效应进行综述,为探究环境中抗抑郁药对人群的健康影响提供参考。With the increasing rise in antidepressant consumption,more and more antidepressants and their metabolic products enter into water and soil environments.This will cause toxicity to animals living in these environments,and antidepressants may be transferred to humans via food chain,leading to human health risks.Based on national and international publications pertaining to environmental pollution and toxic effects of antidepressants during the period between 2005 and 2021,this review summarizes the biological accumulation,acute toxicity,reproductive and developmental toxicity,metabolic effects and biological behavior changes of antidepressants,so as to provide insights into the elucidation of the impact of antidepressants on human health risks.

关 键 词：抗抑郁药 环境污染 生态毒性 

分 类 号：R114[医药卫生—卫生毒理学]