程序性细胞死亡在肝脏缺血-再灌注损伤中的作用研究进展  

Research progress on the role of programmed cell death in hepatic ischemia-reperfusion injury

作　　者：白杨[1] 史冀华[1] 张水军[1] Bai Yang;Shi Jihua;Zhang Shuijun(Department of Hepatobiliary and Pancreatic Surgery,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第一附属医院肝胆胰外科,郑州450052

出　　处：《器官移植》2022年第5期647-652,共6页Organ Transplantation

基　　金：国家自然科学基金(82170670)。

摘　　要：肝移植是治疗终末期肝病的有效手段,但在肝移植过程中不可避免会发生肝脏缺血-再灌注损伤(HIRI),可能导致早期移植物功能障碍或加剧排斥反应,其损伤防护机制有待深入研究。程序性细胞死亡是HIRI的重要发生机制,多种新型程序性细胞死亡形式参与了HIRI的病理过程,深入研究程序性细胞死亡有望进一步提高肝移植的治疗效果。本文就细胞凋亡、自噬及自噬依赖性死亡、铁死亡、坏死性凋亡、细胞焦亡、多聚二磷酸腺苷核糖聚合酶(PARP)-1依赖性细胞死亡等常见的程序性细胞死亡方式在HIRI中的研究进展予以综述,以期为提高肝移植手术成功率、改善受者预后提供参考。Liver transplantation is an effective treatment for the end-stage liver disease. However, hepatic ischemiareperfusion injury(HIRI) will inevitably occur during liver transplantation, which might lead to early graft dysfunction or aggravate rejection. The underlying protective mechanism remains to be further elucidated. Programmed cell death is an important mechanism of HIRI, and multiple novel types of programmed cell death participate in the pathological process of HIRI. In-depth study of programmed cell death is expected to further improve the therapeutic effect of liver transplantation.In this article, research progresses on apoptosis, autophagy and autophagy-dependent cell death, ferroptosis, necroptosis,pyroptosis, pathanatos and other common programmed cell death patterns in HIRI were reviewed, aiming to provide reference for enhancing the success rate of liver transplantation and improving clinical prognosis of the recipients.

关 键 词：肝移植 肝脏缺血-再灌注损伤(HIRI) 程序性细胞死亡 细胞凋亡 自噬 铁死亡 坏死性凋亡 细胞焦亡 多聚二磷酸腺苷核糖聚合酶-1依赖性细胞死亡 

分 类 号：R617[医药卫生—外科学] Q255[医药卫生—临床医学]