和肽素、心钠素及脑钠素对双腔起搏器植入术后心房颤动发生的预测价值  

Predictive value of copeptin,atrial natriuretic peptide and brain natriuretic peptide on atrial fibrillation after dual chamber pacemaker implantation

作　　者：肖红霞 刘长霞 XIAO Hong-xia;LIU Chang-xia(Department of Cardiology,Chengdu BOE Hospital;Department of Gastroenterology and Endocrinology,Sichuan Baoshihua Hospital,Chengdu 610000,Sichuan,China)

机构地区：[1]成都京东方医院心内科 [2]四川宝石花医院消化内分泌科,四川成都610000

出　　处：《川北医学院学报》2022年第8期1008-1012,共5页Journal of North Sichuan Medical College

基　　金：四川省卫生健康委员会科研课题(20PJ310)。

摘　　要：目的:探讨血浆和肽素(CPP)、心钠素(ANP)、脑钠素(BNP)对双腔起搏器植入术后心房颤动(AF)发生的预测价值。方法:选取126例接受双腔起搏器植入术的患者为研究对象,根据术后AF发生情况分为AF组(n=32)和非AF组(n=94)。比较两组患者血浆CPP、ANP、BNP水平,分析其对AF发生的预测价值。结果:AF组患者高血压病史、冠心病病史、左心房内径(LAD)、CPP、ANP、BNP及术后使用β受体阻滞剂病例数高于非AF组(P<0.05);年龄、LAD、高血压、冠心病、β受体阻滞剂使用、CPP、ANP及BNP水平与双腔起搏器植入术后AF发生呈正相关(P<0.05);年龄、LAD、CPP、ANP、BNP、高血压、冠心病是导致双腔起搏器植入术后AF发生的独立危险因素(P<0.05)。CPP、ANP、BNP预测双腔起搏器植入术后AF发生的曲线下面积(AUC)分别为0.839、0.851和0.878,最佳截断值分别为12.76 pmol/L、84.23 pg/mL和178.50 pg/mL。结论:CPP、ANP及BNP是导致双腔起搏器植入术后AF发生的独立危险因素,对双腔起搏器植入术后AF的发生有较高预测价值。Objective:To analyze the predictive value of plasma copeptin(CPP),atrial natriuretic peptide(ANP)and brain natriuretic peptide(BNP)on the occurrence of atrial fibrillation(AF)after dual chamber pacemaker implantation.Methods:126 patients with dual chamber pacemaker implantation were selected and divided into AF group(n=32)and non-AF group(n=94)according to the occurrence of AF after operation.The plasma levels of CPP,ANP and BNP were compared between the two groups,and the predictive value of the threeindicators for AF occurrence was analyzed.Results:The history of hypertension,coronary heart disease,left atrial diameter(LAD),CPP,ANP,BNP and postoperative use of beta blockers in AF group were higher than those in non-AF group(P<0.05).Age,LAD,hypertension,coronary heart disease,beta blockeruse,CPP,ANP and BNP levels were significantly positively correlated with AF after dual chamber pacemaker implantation(P<0.05).Age,LAD,CPP,ANP,BNP,hypertension and coronary heart disease were independent risk factors for AF after dual chamber pacemaker implantation(P<0.05).The area under the curve of CPP,ANP and BNP for predicting AF occurrence after dual chamber pacemaker implantation were 0.839,0.851 and 0.878,respectively,and the best cut-off values were 12.76 pmol/L,84.23 pg/mL and 178.50 pg/mL,respectively.Conclusion:CPP,ANP and BNP are independent risk factors for AF occurrence after dual chamber pacemaker implantation,and have high predictive value for AF after dual chamber pacemaker implantation.

关 键 词：双腔起搏器植入术 心房颤动 和肽素 心钠素 脑钠素 

分 类 号：R541[医药卫生—心血管疾病]