钯催化的偕二氟化合物的双醚化反应  

Palladium-Catalyzed Dietherification of gem-Difluoro Compounds

作　　者：刘新莲 李琳 黄银爱 谭露琪 彭金宝 LIU Xin-lian;LI Lin;HUANG Yin-ai;TAN Lu-qi;PENG Jin-bao(School of Biotechnology and Health Sciences,Wuyi University,Jiangmen 529020,China)

机构地区：[1]五邑大学生物科技与大健康学院,广东江门529020

出　　处：《五邑大学学报（自然科学版）》2022年第3期1-8,共8页Journal of Wuyi University(Natural Science Edition)

基　　金：广东省普通高校创新团队项目(2020KCXTD036);五邑大学青年科研基金团队项目(2019td02);五邑大学大学生创新创业训练计划项目(202111349018);五邑大学学生创新创业项目(2020CX05).

摘　　要：报道了一种新颖的钯催化偕二氟化合物的醚化反应合成烯丙基醚类化合物的方法.以苯酚类化合物和偕二氟化合物作为底物,在醋酸钯的催化作用下,以P(p-tolyl)3为配体、碳酸铯为碱、甲基叔丁基醚为溶剂,在70℃下反应10 h,能以30%~76%的产率得到16种相应的烯丙基醚类衍生物.该反应在较为简单、温和的条件下,不仅有着良好的底物适应性,也能以中等至良好的产率得到目标产物.A novel palladium-catalyzed bis-etherification of gem-difluoro compounds for the synthesis of allyl ethers was reported.Using phenols and difluoride compounds as substrates,palladium acetate as catalyst,P(p-tolyl)_(3) as ligand,cesium carbonate as base and methyl tert-butyl ether as solvent,16 allyl ether derivatives were obtained in 30%~76%yield in reaction at 70℃ for 10 hours.The reaction not only showed good substrate tolerance,but also provided the target products in medium to good yield under relatively simple and mild reaction conditions.

关 键 词：偕二氟化合物 双醚化反应 C—F键 钯催化 

分 类 号：O625[理学—有机化学] TQ222.4[理学—化学]