细胞因子在慢性乙型肝炎治疗中的研究进展  

Research advances in cytokines in the treatment of chronic hepatitis B

作　　者：高子翔 沈忠良[1,2] 刘晶 谢幼华[1,4] GAO Zixiang;SHEN Zhongliang;LIU Jing;XIE Youhua(Key Laboratory of Medical Molecular Virology(MOE/NHC/CAMS)and Department of Medical Microbiology and Parasitology,School of Basic Medical Sciences,Shanghai Medical College,Fudan Uni-versity,Shanghai 200032,China;Department of Infectious Diseases,Shanghai Key Laboratory of Infectious Diseases and Biosafety Emer-gency Response,National Medical Center for Infectious Diseases,Huashan Hospital,Fudan University,Shanghai 200040,China;Institu-tes of Biomedical Sciences,School of Basic Medical Sciences,Shanghai Medical College,Fudan University,Shanghai 200032,China;Shanghai Institute of Infectious Disease and Biosecurity,Fudan University,Shanghai 200032,China)

机构地区：[1]复旦大学教育部/卫健委/医科院医学分子病毒学重点实验室,上海医学院基础医学院病原生物学系,上海200032 [2]复旦大学附属华山医院感染科,上海市传染病与生物安全应急响应重点实验室,国家传染病医学中心,上海200040 [3]复旦大学生物医学研究院,上海200032 [4]上海市重大传染病和生物安全研究院,上海200032

出　　处：《临床肝胆病杂志》2022年第8期1710-1715,共6页Journal of Clinical Hepatology

基　　金：国家自然科学基金(81971921)。

摘　　要：目前,全球范围内仍有约2.5亿人慢性感染HBV,严重威胁人类的生命健康。慢性乙型肝炎(CHB)可进一步发展为肝纤维化、肝硬化和肝细胞癌等肝脏疾病,而现有的临床抗病毒治疗药物有限,治愈率很低,急需研发新型抗病毒药物。HBV具有强嗜肝性,自然情况下只感染人、黑猩猩等少数灵长类动物。免疫反应(固有免疫与适应性免疫)能否有效识别并清除或抑制HBV是导致病毒感染后不同结局的重要因素。其中,细胞因子发挥了重要的免疫调节作用。本文就一些关键细胞因子在CHB感染及治疗中的研究进展进行了总结与讨论。At present,there are still about 250 million people with chronic hepatitis B virus(HBV)infection around the world,which seri-ously threatens human life and health.Chronic hepatitis B(CHB)can develop into liver diseases such as liver fibrosis,liver cirrhosis,and hepatocellular carcinoma;however,there is still a limited number of antiviral drugs and an extremely low cure rate in clinical practice,and thus it is urgent to develop new antiviral drugs.HBV has strong hepatotropism and only infects a few primates such as humans and chimpan-zees under natural conditions.Whether immune response(innate immunity and adaptive immunity)can effectively recognize and eliminate or inhibit HBV is an important factor leading to different outcomes after virus infection,and cytokines play an important immunoregulatory role in this process.This article summarizes and discusses the research advances in some key cytokines in CHB infection and treatment.

关 键 词：乙型肝炎病毒 细胞因子类 乙型肝炎 慢性 治疗学 

分 类 号：R512.62[医药卫生—内科学]