奇壬醇对骨质疏松症的治疗作用及机制研究进展  

Research progress on therapeutic effect and mechanism of Kirenol on osteoporosis

作　　者：昌震[1] 李大同 杨小彬[1] 孔令擘 孙杨 CHANG Zhen;LI Datong;YANG Xiaobin;KONG Lingbo;SUN Yang(Department of Spine Surgery,Honghui Hospital Affiliated to Xi’an Jiaotong University,Xi’an 710054,China)

机构地区：[1]西安交通大学附属红会医院脊柱外科,陕西西安710054 [2]汉中职业技术学院附属医院骨显微外科,陕西汉中723000

出　　处：《陕西医学杂志》2022年第9期1167-1170,共4页Shaanxi Medical Journal

基　　金：陕西省自然科学基础研究计划项目(2021JM-575)。

摘　　要：骨质疏松症是一种多因素导致的骨质流失疾病,大大增加了骨折的风险。目前骨质疏松症主要依靠药物治疗,但长期药物治疗中都存在安全性和耐受性问题。高效低毒天然药物的研发逐渐受到青睐,为骨质疏松症的治疗带来了新的转变。奇壬醇(Kir)作为具有生物活性的二萜类化合物,能够通过抑制多种信号通路来抑制破骨细胞的活性,为骨质疏松症的治疗提供了新的前瞻性思路。现就Kir对骨质疏松症的治疗作用及机制进展进行综述。Osteoporosis is a multifactorial bone loss disease that greatly increases the risk of fracture.At present,osteoporosis mainly depends on drug therapy,but there are safety and tolerability problems in long-term drug therapy.The research and development of high-efficiency and low-toxicity natural drugs are gradually gaining popularity,bringing new changes to the treatment of osteoporosis.Kirenol(Kir),as a biologically active diterpenoid,can inhibit the activity of osteoclasts by inhibiting various signal pathways,thus providing a new prospective idea for the treatment of osteoporosis.This article reviews the therapeutic effect and mechanism of Kir on osteoporosis.

关 键 词：骨质疏松症 奇壬醇 破骨细胞 天然药物 信号通路 

分 类 号：R580[医药卫生—内分泌]