短肽超分子自组装驱动力及调控策略的研究发展  

Research Progress of Regulation of Driving Forces in Short Peptide Supramolecular Self-Assembly

作　　者：张伟强 王晨 赵玉荣 王栋 王继乾 徐海 ZHANG Wei-Qiang;WANG Chen;ZHAO Yu-Rong;WANG Dong;WANG Ji-Qian;XU Hai(Center for Bioengineering&Biotechnology,College of Chemical Engineering,China University of Petroleum(East China),Qingdao 266580,China)

机构地区：[1]中国石油大学(华东)化学工程学院生物工程与技术中心,青岛266580

出　　处：《应用化学》2022年第8期1190-1201,共12页Chinese Journal of Applied Chemistry

基　　金：国家自然科学基金项目(Nos.22072181,U1832108)资助。

摘　　要：短肽分子在弱相互作用力驱动下可以自发形成形貌多样的自组装体。这些弱相互作用力包括静电作用、氢键作用和π-π堆积作用等,它们相互耦合,协同驱动短肽自组装过程。通过对短肽分子有目的性的序列设计和修饰,可以针对性调节自组装驱动力,从而实现对自组装体结构和形貌的有效调控,进而实现肽基超分子材料的可控制造与功能化。本文系统综述了氢键作用、π-π堆积作用、静电作用、疏水效应、金属离子配位和手性中心等因素对短肽自组装行为的影响规律,以及通过氨基酸序列设计与分子修饰、改变溶液pH值和短肽分子浓度、金属离子配位等因素对组装驱动力的调控机制。最后,对肽基超分子材料在生物医学、生物催化等领域的特定功能开发进行了展望。Some short peptides can spontaneously self-assemble into various nanostructures via the synergistic driving forces of non-covalent interactions.These non-covalent interactions,including electrostatic interaction,hydrogen bonding,aromatic interactions and other non-covalent interactions,are usually highly coupled together.Through rational sequence design and proper modification of short peptide molecules,the driving forces could be regulated purposively,and the nanostructures and morphologies of the self-assemblies could be controlled accordingly,and thus so as to achieve the fabrication of peptide-based supramolecular biomaterials and develop their functions.In this paper,the effects of hydrogen bonding,π-πstacking,electrostatic interaction,hydrophobic interaction,metal ion coordination and chiral center on the selfassembly behavior of peptide self-assembly have been reviewed.The driving force regulation strategies,including sequence design,p H and concentration adjustment and metal ion coordination,and the resulted nanostructures have also been discussed.We also make the outlooks on the development of peptide-based supramolecular biomaterials with specific functions in biomedicines and biocatalysis.

关 键 词：短肽自组装 氢键 Π-Π堆积 静电作用 疏水作用 配位作用 手性 

分 类 号：O641.3[理学—物理化学]