水性聚硅氧烷和聚乙烯醇复合物制备及其作为皮肤屏障材料的性能  

Preparation and Properties Characterization of Hydrophilic Polysiloxane and Polyvinyl Alcohol Composite as Skin Barrier Material

作　　者：陈炳刚 刘三荣[1] 蒋子江[2] 于喜飞 CHEN Bing-Gang;LIU San-Rong;JIANG Zi-Jiang;YU Xi-Fei(Laboratory of Polymer Composites Engineering,Changchun Institute of Applied Chemistry,Chinese Academy of Science,Changchun 130022,China;National Analytical Research Center of Electrochemistry and Spectroscopy,Changchun Institute of Applied Chemistry,Chinese Academy of Science,Changchun 130022,China;University of Science and Technology of China,Hefei 230026,China)

机构地区：[1]中国科学院长春应用化学研究所,高分子复合材料工程实验室,长春130022 [2]中国科学院长春应用化学研究所,国家电化学和光谱研究分析中心,长春130022 [3]中国科学技术大学,合肥230026

出　　处：《应用化学》2022年第8期1224-1236,共13页Chinese Journal of Applied Chemistry

基　　金：国家自然科学基金项目(No.21674109)资助。

摘　　要：皮肤作为人体最外层的器官,容易遭受损伤,构建能够为皮肤提供保护作用的屏障材料具有非常重要的意义。基于皮肤屏障材料性能要求,将亲水改性的聚硅氧烷(PSI)和聚乙烯醇(PVA)相结合,通过原位Ca2+离子交联构建了一种复合多功能的皮肤屏障材料PSI-PVA。研究表明,该材料具有较好的干态和湿态力学性能,以及较好的皮肤相容性、可清洗性、亲水性、透气性、可修饰性和生物相容性。当PVA质量分数为20%时,溶胀率可达149%;随着PVA用量的增加,材料的清洗容易程度提高;紫外吸收剂羟基苯甲酮修饰后,材料的紫外光(200~400 nm)透过率在20%以下,在材料的保护下,小鼠胚胎成纤维细胞(NIH 3T3)在UVB(311 nm)照射后具有较高的存活率(71%)。因此,PSI-PVA可以满足皮肤屏障材料多项性能需求,在皮肤保护和受损修复等领域具有较好的应用前景。As the outermost organ of human body,skin is easily injured.Therefore,it is more important to construct protected barrier material for skin.Herein,based on the performance requirement of skin barrier material,we construct a multifunctional skin barrier material PSI-PVA by combining hydrophilically modified polysiloxane(PSI)and polyvinyl alcohol(PVA)through ionic crosslinking.The test results indicate that PSI-PVA exhibits good stretchability in dry and wet and has compatible mechanical properties like skin.PSI-PVA is hydrophilic and the swelling ratio is up to 149%with the PVA content of 20%,and water can volatilize rapidly at room temperature,which makes PSI-PVA good breathability.PSI-PVA has good cleaning performance and can be easily cleaned from skin with water.In addition,PSI-PVA covalently linked with UV-absorbing group of hydroxybenzophenone can effectively decrease UV transmittance.The in vitro experiment indicates that NIH 3T3 cells have high survival rate(71%)irradiated by UVB(311 nm)with the protection of the PSI-PVA film.Furthermore,PSI-PVA also exhibits good biocompatibility through cell viability assay.The skin barrier material PSI-PVA constructed with composite of polysiloxane and polyvinyl alcohol can meet properties requirements and has good application prospects in fields of skin protection and injury repair.

关 键 词：聚硅氧烷 亲水改性 聚乙烯醇 离子交联 皮肤屏障材料 

分 类 号：O633.1[理学—高分子化学]