鼻渊通窍方加减联合糠酸莫米松鼻喷剂治疗慢性鼻-鼻窦炎的疗效及安全性分析  

Efficacy and safety of modified Biyuan Tongqiao formula combined with mometasone furoate nasal spray in the treatment of chronic rhinosinusitis

作　　者：孙艺 程向荣 顾晓娜[1] 张鹏[1] Sun Yi;Cheng Xiangrong;Gu Xiaona;Zhang Peng(Department of Otolaryngology,integrated traditional Chinese and Western Medicine Hospital Affiliated to Nanjing University of traditional Chinese medicine(Jiangsu integrated traditional Chinese and Western Medicine Hospital),Nanjing,Jiangsu,210003,China)

机构地区：[1]南京中医药大学附属中西医结合医院(江苏省中西医结合医院),江苏南京210003

出　　处：《中国医学文摘（耳鼻咽喉科学）》2022年第4期41-44,12,共5页Chinese Medical Digest(Otorhinolaryngology)

摘　　要：目的 探讨并发慢性鼻-鼻窦炎的患者在糠酸莫米松鼻喷剂给药基础上,取鼻渊通窍方加减治疗所取得的效果及安全性。方法 选取并发慢性鼻-鼻窦炎的患者共计60例,均为我院2021年1月至2021年12月期间收治,采用随机数字表抽取法做分组处理,其中对照组针对所纳入的30例单用糠酸莫米松鼻喷剂予以治疗,观察组针对所纳入的30例同时取鼻渊通窍方加减方案联用。就两组总有效率评定值、炎性因子指标水平、中医症候积分评测分值、鼻黏膜形态评测分值、不良反应率展开对比。结果 经对观察组所纳入的患者总有效率展开评定为93.33%,对照组展开评定为70.00%,前者高于后者(P<0.05)。两组在开展治疗工作前,经对血清炎性因子即TNF-α、IL-6、IL-17进行测定,差异无统计学意义(P>0.05),在开展治疗后,各项测定值均有降低,且相较对照组,观察组居更低水平,差异具有统计学意义(P<0.05)。两组在开展治疗工作前,经对中医证候积分即鼻塞、大便溏薄、鼻涕浑浊、少气疲乏进行测定,差异无统计学意义(P>0.05)。在开展治疗后,各项评测分值均有降低,且观察组更为显著,差异具有统计学意义(P<0.05)。两组在开展治疗工作前,经对鼻内镜指标即脓性分泌物、黏液性分泌物、黏膜炎症状态评分进行评定,无统计学差异(P>0.05),在开展治疗后,各项评测分值具有降低,且相较对照组,观察组居更低水平(P<0.05)。两组头晕、鼻腔干燥等不良反应率经观测无统计学差异(P>0.05)。结论 针对临床所收治的并发慢性鼻-鼻窦炎的患者,在采用糠酸莫米松鼻喷剂予以治疗基础上,取鼻渊通窍方加减方案联用,可增强临床治疗总有效率,降低血清炎性因子水平,改善临床症状及体征,且具较高安全性,开展价值显著。Objective To investigate the effect and safety of adding and subtracting Biyuan Tongqiao formula on the basis of mometasone furoate nasal spray in patients with chronic rhinosinusitis.Methods A total of 60 patients with chronic rhinosinusitis were selected and treated in our hospital from January 2021 to December 2021.They were divided into groups by random number table.30 patients in the control group were treated with mometasone furoate nasal spray alone,and 30 patients in the observation group were treated with the addition and subtraction of Biyuan Tongqiao formula.The total effective rate,inflammatory factor index level,TCM symptom score,nasal mucosa morphology score and adverse reaction rate were compared between the two groups.Results The total effective rate was 93.33% in the observation group and 70.00% in the control group (P<0.05).Before the treatment,the serum inflammatory factor TNF-α、 IL-6 and IL-17 were measured,and there was no significant difference (P>0.05).After the treatment,the measured values were reduced,and compared with the control group,the observation group was at a lower level,and the difference was statistically significant (P<0.05).Before treatment,there was no significant difference between the two groups (P>0.05).After the treatment,the scores of each evaluation decreased,and the difference was statistically significant in the observation group (P<0.05).Before the treatment,there was no significant difference between the two groups in the scores of nasal endoscopy indexes,namely purulent secretion,mucinous secretion and mucosal inflammation (P>0.05).After the treatment,the scores of each evaluation decreased,and the observation group was at a lower level than the control group (P<0.05).There was no significant difference in the adverse reaction rates of dizziness and nasal dryness between the two groups (P>0.05).Conclusion For the patients with chronic rhinosinusitis treated in clinic,on the basis of using mometasone furoate nasal spray,the combination of the addition and subtra

关 键 词：慢性鼻-鼻窦炎 糠酸莫米松鼻喷剂 鼻渊通窍方 总有效率 不良反应 

分 类 号：R27[医药卫生—中医学]