肠道菌群代谢物——短链脂肪酸的研究进展  

Research progress of short-chain fatty acids metabolites of gut microbiota

作　　者：杨艳青 李灿委 杨自忠 张成桂 高鹏飞 YANG Yanqing;LI Canwei;YANG Zizhong;ZHANG Chenggui;GAO Pengfei(College of Pharmacy,Dali University,Dali 671000,China;Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D,Dali 671000,China;Engineering Research Center of Exploitation and Comprehensive Utilization of Medicinal Insect Resources,Education Department of Yunnan Province,Dali 671000,China)

机构地区：[1]大理大学药学院,云南大理671000 [2]云南省昆虫生物医药研发重点实验室,云南大理671000 [3]药用昆虫资源开发与综合利用云南省教育厅工程研究中心,云南大理671000 [4]大理大学公共卫生学院,云南大理671000

出　　处：《实用医学杂志》2022年第14期1834-1837,共4页The Journal of Practical Medicine

基　　金：国家自然科学基金资助项目(编号:81260676,81560663,81960712,32160113);中国国家留学基金(编号:201708535007);云南省重大科技专项计划—生物资源数字化开发应用(编号:202002AA100007)。

摘　　要：肠道菌群代谢物——短链脂肪酸(short chain fatty acids,SCFAs)具有较为丰富的生物学作用,可参与机体的免疫调节,促进免疫细胞分化成熟;维持菌群平衡,抑制有害菌生长繁殖,促进有益菌生长;促进肠道消化吸收,加快胃肠道蠕动;调节机体糖脂代谢。本文通过总结SCFAs代谢过程、生物学功能,探究其对机体健康的影响,为SCFAs研究提供理论依据。Short chain fatty acids(SCFAs),metabolites of gut microbiota,haveabundant biological effects,participate in the immune regulation of the body and promote the differentiation and maturation of immune cells.Maintain the balance of gut microbiota,inhibit the growth and reproduction of harmful bacteria,and promote the growth of beneficial bacteria;Promote intestinal digestion and absorption,accelerate gastrointestinal peristalsis;Regulation of body glycolipid metabolism.Via summarizingthemetabolic process and biological functions of SCFAs,this paper exploresits influence on body health,providing theoretical basis for SCFAs research.

关 键 词：短链脂肪酸 生物学作用 免疫 肠道菌群 

分 类 号：R378[医药卫生—病原生物学]