新型冠状病毒感染者密切接触者的密切接触者感染风险分析  

Analysis on infection risk in secondary close contacts of COVID-19 patients

作　　者：易波[1] 褚衍茹 陈奕[1] 张栋梁[1] 张言武 雷松 洪潞[2] 李巧方 顾晓敏[1] 劳旭影[1] 王海波[1] 林君芬[4] 许国章[1] Yi Bo;Chu Yanru;Chen Yi;Zhang Dongliang;Zhang Yanwu;Lei Song;Hong Lu;Li Qiaofang;Gu Xiaomin;Lao Xuying;Wang Haibo;Lin Junfen;Xu Guozhang(Ningbo Prefectural Center for Disease Control and Prevention,Ningbo 315010,China;Zhenhai District Center for Disease Control and Prevention,Ningbo 315200,China;Beilun District Center for Disease Control and Prevention,Ningbo 315800,China;Zhejiang Provincial Center for Disease Control and Prevention,Hangzhou 310051,China)

机构地区：[1]宁波市疾病预防控制中心,宁波315010 [2]宁波市镇海区疾病预防控制中心,宁波315200 [3]宁波市北仑区疾病预防控制中心,宁波315800 [4]浙江省疾病预防控制中心,杭州310051

出　　处：《中华流行病学杂志》2022年第8期1237-1240,共4页Chinese Journal of Epidemiology

基　　金：宁波市科技重大专项-新型冠状病毒肺炎疫情防控应急科技攻关项目(2020C50001);宁波市“科技创新2025”重大专项(2021Z021);宁波市医疗卫生品牌学科(PPXK2018-10);宁波市应急科技攻关重大专项(2022Z034)。

摘　　要：目的研究新型冠状病毒(新冠病毒)感染者密切接触者(密接)的密接(次密接)感染率,评估新冠病毒感染者次密接的感染风险。方法采用前瞻性研究的方法,对进入集中隔离医学观察时且采样检测核酸结果为阴性的密接(与指示病例有明确的暴露时间)及其次密接进行持续医学观察,收集新冠病毒感染者密接和次密接的动态核酸检测结果,评估密接和次密接的感染风险。结果追踪调查了符合纳入条件的密接4533例,14例密接转归为新冠病毒感染者,感染率为0.31%。共追踪了次密接4201例,均未发生后续感染。结论密接进入集中隔离医学观察时采样检测核酸结果为阴性,该次密接无感染风险。Objective To study the infection rate of secondary close contacts of COVID-19 patients,and assess the infection risk in the contacts.Methods COVID-19 patients'close contacts(with a clear exposure time to index case)with negative nucleic acid test results and secondary close contacts were surveyed in continuous isolation and medical observation in this prospective study.The dynamic nucleic acid test results of the close contacts and secondary contacts of COVID-19 patients were collected to assess their risk of infection.Results A total of 4533 close contacts were surveyed,in whom 14 were confirmed as COVID-19 patients with overall secondary attack rate of 0.31%,and 4201 secondary contacts were tracked,in whom no subsequent infections occurred.Conclusion Close contacts of COVID-19 patients entered in centralized isolation for medical observation with negative nucleic acid tese results,the secondary close contacts of COVID-19 patients have no risk of infection.

关 键 词：新型冠状病毒 密切接触者 次密接 感染风险 

分 类 号：R563.1[医药卫生—呼吸系统] R181.8[医药卫生—内科学]