中国成年双生子饮茶行为分布特征  

A descriptive analysis of tea consumption in adult twins in China

作　　者：毋之钰 高文静[1] 曹卫华[1] 吕筠[1] 余灿清[1] 王胜锋[1] 黄涛 孙点剑一 廖春晓[1] 庞元捷[1] 逄增昌[2] 俞敏[3] 汪华[4] 吴先萍[5] 董忠[6] 吴凡[7] 江国虹[8] 王晓节[9] 刘彧 邓健[11] 陆林[12] 李立明[1] Wu Zhiyu;Gao Wenjing;Cao Weihua;Lyu Jun;Yu Canqing;Wang Shengfeng;Huang Tao;Sun Dianjianyi;Liao Chunxiao;Pang Yuanjie;Pang Zengchang;Yu Min;Wang Hua;Wu Xianping;Dong Zhong;Wu Fan;Jiang Guohong;Wang Xiaojie;Liu Yu;Deng Jian;Lu Lin;Li Liming(Department of Epidemiology and Biostatistics,School of Public Health,Peking University Health Science Center,Beijing 100191,China;Qingdao Center for Disease Control and Prevention,Qingdao 266033,China;Zhejiang Center for Disease Control and Prevention,Hangzhou 310051,China;Jiangsu Center for Disease Control and Prevention,Nanjing 210009,China;Sichuan Center for Disease Control and Prevention,Chengdu 610041,China;Beijing Center for Disease Prevention and Control,Beijing 100013,China;Shanghai Center for Disease Control and Prevention,Shanghai 200336,China;Tianjin Center for Disease Control and Prevention,Tianjin 300011,China;Qinghai Center for Disease Control and Prevention,Xining 810007,China;Heilongjiang Center for Disease Control and Prevention,Harbin 150090,China;Handan Center for Disease Control and Prevention,Handan 056001,China;Yunnan Center for Disease Control and Prevention,Kunming 650034,China)

机构地区：[1]北京大学公共卫生学院流行病与卫生统计学系,北京100191 [2]青岛市疾病预防控制中心,青岛266033 [3]浙江省疾病预防控制中心,杭州310051 [4]江苏省疾病预防控制中心,南京210009 [5]四川省疾病预防控制中心,成都610041 [6]北京市疾病预防控制中心,北京100013 [7]上海市疾病预防控制中心,上海200336 [8]天津市疾病预防控制中心,天津300011 [9]青海省疾病预防控制中心,西宁810007 [10]黑龙江省疾病预防控制中心,哈尔滨150090 [11]邯郸市疾病预防控制中心,邯郸056001 [12]云南省疾病预防控制中心,昆明650034

出　　处：《中华流行病学杂志》2022年第8期1241-1248,共8页Chinese Journal of Epidemiology

基　　金：公益性行业科研专项(201502006,201002007);国家自然科学基金(81973126,82073633)。

摘　　要：目的描述中国双生子登记系统(CNTR)成年双生子饮茶行为的分布特征,探索饮茶行为在双生子人群中的分布规律,为探究遗传和环境因素对饮茶行为的影响提供线索。方法样本选自2010-2018年在CNTR进行登记的双生子,纳入≥18岁且具有饮茶信息的双生子共25264对进行分析,描述双生子中饮茶行为的人群、地区分布特征,以及不同卵型双生子饮茶行为一致率和对内饮茶量差异分布情况。结果研究对象年龄(35.38±12.45)岁,每周饮茶者占比17.0%,饮茶量(3.36±2.44)杯/d。男性、50~59岁、南方、城镇、文化程度高、双生子中先出生的个体中每周饮茶者比例较高(P<0.05),未婚者中比例较低(P<0.001)。双生子对内分析发现同卵饮茶行为一致率均大于异卵,饮茶遗传度为13.45%(11.38%~15.51%),除女性亚组外,不同性别、年龄、地区间饮茶一致率差异有统计学意义(均P<0.05);根据性别、年龄、地区分层后仅男性同卵一致率始终呈大于异卵趋势。同性别双生子对内饮茶量差异在男性中呈现同卵小于异卵的特征(P<0.05),而女性中差异不明显。结论本研究双生子人群饮茶行为的分布存在人群和地区差异,饮茶行为主要受环境因素影响,遗传因素影响较弱,且遗传效应大小在不同性别、年龄、地区间不尽相同,性别可修饰这一遗传作用。Objective To describe the distribution characteristics of tea consumption in adult twins recruited in the Chinese National Twin Registry(CNTR)and provide clues to genetic and environmental influences on tea consumption.Methods Enrolled in CNTR during 2010-2018,25264 twin pairs aged 18 years and above were included in subsequent analysis.Random effect models were used to estimate tea consumption in the population and regional distribution characteristics.The concordance rate of the behavior and difference in consumption volume of tea within pairs were also described.Results The mean age of all subjects was(35.38±12.45)years old.The weekly tea consumers accounted for 17.0%,with an average tea consumption of(3.36±2.44)cups per day.The proportion of weekly tea consumers was higher among males,50-59 years old,southern,urban,educated,and the first-born in the twin pair(P<0.05),and lower among unmarried individuals(P<0.001).Within-pair analysis showed that the concordance rate of tea consumption of monozygotic(MZ)twins was higher than that of dizygotic(DZ)twins and the overall heritability of tea consumption was 13.45%(11.38%-15.51%).Stratified by the characteristics mentioned above,only in males,the concordance rate of MZ showed a tendency to be greater than that of DZ(all P<0.05).The differences in consumption volume of tea within twin pairs were minor in MZ among males(P<0.05),while the differences were not significant in female twins.Conclusion There were discrepancies in the distribution of tea consumption among twins of different demographic and regional characteristics.Tea consumption was mainly influenced by environmental factors and slightly influenced by genetic factors.The size of genetic factors varied with gender,age,and region,and gender was a potential modified factor.

关 键 词：饮茶 双生子 遗传 环境 

分 类 号：R195[医药卫生—卫生统计学]