ApoB100对肝脏VLDL合成分泌的影响及其在兽医临床中的研究进展  

Effect of ApoB100 on synthesis and secretion of hepatic VLDL and its research progress in veterinary clinic

作　　者：范文文 王爽[1] 高畅鸿 田艳 邹存志 徐闯[1] 张冰冰 杨威 Fan Wenwen;Wang Shuang;Gao Changhong;Tian Yan;Zou Cunzhi;Xu Chuang;Zhang Bingbing;Yang wei(College of Animal Science and Technology,Heilongjiang Bayi Agricultural University,Heilongjiang Daqing 163319;COllge of Life Science and Technology,Heilongjiang Bayi Agriultural University,Heilongjiang Daqing 13319)

机构地区：[1]黑龙江八一农垦大学动物科技学院,黑龙江大庆163319 [2]黑龙江八一农垦大学生命科学技术学院,黑龙江大庆163319

出　　处：《现代畜牧兽医》2022年第7期89-93,共5页Modern Journal of Animal Husbandry and Veterinary Medicine

基　　金：国家自然基金项目(U20A2062);黑龙江省博士后科研启动项目(2020-51)。

摘　　要：肝脏可从循环中获得脂质,进行合成并将脂质中的脂蛋白分泌至血液中,在全身新陈代谢的动态平衡中起到核心作用。极低密度脂蛋白(VLDL)是肝脏的主要分泌产物,其主要作用是向外周组织运输内源性合成的脂类,如甘油三酯(TG)等。载脂蛋白B100 (ApoB100)作为VLDL颗粒中主要和必需的蛋白质,与大多数肝脏分泌蛋白的合成不同,主要由共降解和翻译后降解进行调节。文章就ApoB100通过降解及自噬作用影响奶牛肝脏VLDL的合成分泌以及ApoB100在兽医临床中的相关研究进行概述,以期为未来的相关研究提供参考。The liver can obtain lipids from the circulation, synthesize and secrete lipoproteins in lipids into the blood, and play a central role in the homeostasis of systemic metabolism. Very low-density lipoprotein(VLDL) is the main secretion product of the liver, and its main role is to transport endogenously synthesized lipids, such as triglycerides(TG), to peripheral tissues. Apolipoprotein B100(ApoB100), as the major and essential protein in VLDL particles, which is mainly regulated by co-and post-translational degradation, unlike the synthesis of most hepatic secreted proteins. The article summarizes the effect of ApoB100 on the synthesis and secretion of VLDL in the liver of dairy cows through degradation and autophagy, as well as the related research of ApoB100 in veterinary clinics, in order to provide a reference for future related research.

关 键 词：肝脏 极低密度脂蛋白 载脂蛋白B100 自噬 降解 

分 类 号：S856[农业科学—临床兽医学]