度拉糖肽对2型糖尿病患者外周血内皮祖细胞数量的影响  

Effect of Dulaglutide on the number of endothelial progenitor cells in peripheral blood of patients with type 2 diabetes mellitus

作　　者：吕淑芳 赵晓彤[1] 许慕蓉 解丹丹 方朝晖[2] 陈明卫[1] LV Shufang;ZHAO Xiaotong;XU Murong;XIE Dandan;FANG Zhaohui;CHEN Mingwei(Department of Endocrinology,The First Affiliated Hospital of Anhui Medical University,Hefei,230032,China;Department of Endocrinology,The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine)

机构地区：[1]安徽医科大学第一附属医院内分泌科,合肥230032 [2]安徽中医药大学第一附属医院内分泌科

出　　处：《临床心血管病杂志》2022年第7期572-576,共5页Journal of Clinical Cardiology

基　　金：安徽高校合作攻关和公共卫生协同创新项目(No:GXXT-2020-025)。

摘　　要：目的:了解度拉糖肽对2型糖尿病(T2DM)患者外周血内皮祖细胞(EPCs)数量的影响及其相关因素。方法:选取60例口服二甲双胍1000mg/d治疗的T2DM患者,随机分为二甲双胍增量组(MET组,30例,口服二甲双胍2000mg/d)和二甲双胍联合度拉糖肽治疗组(MET-DUL组,30例,二甲双胍1000mg/d联合度拉糖肽1.5mg/周皮下注射),持续治疗4周。采用流式细胞术检测治疗前后CD34、CD133、KDR均为阳性的EPCs数量。结果:经4周治疗后,MET组外周血EPCs数量改变无统计学意义(P>0.05),而MET-DUL组中外周血EPCs数量[(45.8±11.6)/106cell∶(26.1±13.4)/106cell],一氧化氮(NO)[(118.9±18.6)μmol/L∶(71.6±13.9)μmol/L]均高于治疗前(P<0.05),BMI[(26.3±2.6)kg/m^(2):(27.1±2.5)kg/m^(2)]低于治疗前(P<0.05)。MET-DUL组中ΔEPCs与ΔBMI、ΔFPG相关系数(r)为-0.296、-0.218(P<0.05),与ΔNO的r为0.389(P<0.05)。结论:度拉糖肽可提高T2DM患者外周血EPCs数量。Objective To understand the effect of dulaglutide on the number of endothelial progenitor cells(EPCs)in peripheral blood of patients with type 2 diabetes mellitus(T2DM)and its related factors.Methods A total of 60 T2DM patients treated with oral metformin 1000 mg/day were selected and randomly divided into metformin incremental group(MET group,30 cases,oral metformin 2000 mg/day)and metformin combined with dulaglutide treatment group(MET-DUL Group,30 cases,metformin 1000 mg/day combined with subcutaneous injection of dulaglutide 1.5 mg/week)for 4 weeks.Flow cytometry was used to detect the number of EPCs positive for CD34,CD133 and KDR before and after treatment.Results After 4 weeks of treatment,the number of peripheral blood EPCs in the MET group did not change significantly(P>0.05),while the number of peripheral blood EPCs in the MET-DUL group[(45.8±11.6)/106 cell vs(26.1±13.4)/106 cell],nitric oxide(NO)[(118.9±18.6)μmol/L vs(71.6±13.9)μmol/L]were higher than those before treatment(P<0.05),BMI[(26.3±2.6)kg/m2:(27.1±2.5)kg/m2]was lower than that before treatment(P<0.05).In the MET-DUL group,the correlation coefficients(r)ofΔEPCs withΔBMI andΔFPG were-0.296,-0.218,and the r withΔNO was 0.389(P<0.05).Conclusion Dulaglutide can increase the number of blood EPCs in T2DM patients.

关 键 词：度拉糖肽 糖尿病 2型 内皮祖细胞 一氧化氮 

分 类 号：R541[医药卫生—心血管疾病]