SUMO化修饰在精子发生过程中的作用  

Role of SUMOylation in spermatogenesis

作　　者：栾家妍 李朋 韩邦旻 LUAN Jiayan;LI Peng;HAN Bangmin(Urology Clinical Medical Center,Shanghai General Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200080,China)

机构地区：[1]上海交通大学医学院附属第一人民医院泌尿外科临床医学中心,上海200080

出　　处：《上海交通大学学报（医学版）》2022年第7期925-930,共6页Journal of Shanghai Jiao tong University:Medical Science

基　　金：上海市“科技创新行动计划”医学创新研究专项项目(20Y11907600);国家自然科学基金(82171586)。

摘　　要：SUMO化修饰(SUMOylation)是一种可逆的蛋白质翻译后修饰方式,参与转录调节、信号转导及DNA损伤修复等多个重要的生物学过程。研究发现,SUMO化修饰的整体表达和定位在精子的发生过程中呈动态变化,推测其可能参与了精子发生中的关键事件。精子发生是由复杂网络调控的一系列过程,即在生精小管中生精细胞经精原干细胞的增殖和分化、精母细胞的减数分裂以及精子变形3个阶段,最终形成高度特化的成熟精子。而在这一过程中,SUMO化修饰的作用及其具体机制尚未被明确。因此,该文就SUMO化修饰酶系、SUMO家族以及SUMO特异性蛋白酶家族在精子发生过程中的作用进行综述。SUMOylation is a reversible post-translational modification of proteins,which is involved in many important biological processes,such as transcriptional regulation,signal transduction,and DNA damage repair.It is found that the overall expressions and localizations of SUMOylation change dynamically in spermatogenesis,suggesting that it may be involved in key events in the process.Spermatogenesis is a series of processes regulated by complex biological crosstalk.In the seminiferous tubules,spermatogenic cells undergo three stages,that is,the proliferation and differentiation of spermatogonial stem cells,the meiosis of spermatocytes and spermiogenesis,and eventually form highly specialized spermatozoa.In this process,the effects and mechanisms of SUMOylation in spermatogenesis have not been clear.Therefore,this review summarizes the effect of the SUMOylation enzyme system,SUMO family and SUMO-specific proteases family in spermatogenesis.

关 键 词：精子发生 SUMO化修饰 翻译后修饰 

分 类 号：R339.21[医药卫生—人体生理学]