超极化^(129)Xe自动收集-升华装置研究  

Study on the Automatic Accumulation-thawing Device of Hyperpolarized ^(129)Xe

作　　者：陈小明 赵修超 孙献平 谢军帅 李海东 韩叶清 刘小玲 陈琪 周欣 CHEN Xiao-ming;ZHAO Xiu-chao;SUN Xian-ping;XIE Jun-shuai;LI Hai-dong;HAN Ye-qing;LIU Xiao-ling;CHEN Qi;ZHOU Xin(State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics,National Center for Magnetic Resonance in Wuhan,Innovation Academy for Precision Measurement Science and Technology,Chinese Academy of Sciences,Wuhan 430071,China;University of Chinese Academy of Sciences,Beijing 100049,China)

机构地区：[1]中国科学院精密测量科学与技术创新研究院,波谱与原子分子物理国家重点实验室,武汉磁共振中心,湖北武汉430071 [2]中国科学院大学,北京100049

出　　处：《波谱学杂志》2022年第3期316-326,共11页Chinese Journal of Magnetic Resonance

基　　金：国家自然科学基金资助项目(11905288,82127802).

摘　　要：因其较高的核自旋极化度所提供的探测灵敏度,超极化^(129)Xe气体已被成功应用于动物和人体磁共振成像(MRI).但是,在超极化^(129)Xe的收集-升华过程中,多种因素会导致^(129)Xe核自旋弛豫,进而限制其应用范围.本文通过理论模型分析和实验测量,验证了温度、磁场、螺旋冷阱材质等对冷冻恢复过程中超极化^(129)Xe弛豫的影响;同时,测量了自动收集-升华装置的稳定性.研究结果表明,升华方式和冷阱材质对^(129)Xe极化度损耗的影响显著;自制收集-升华装置的自动化程度高、长时间稳定,^(129)Xe极化度的恢复率可达到85.6%±4.7%.本研究非常有助于提升超极化^(129)Xe在动物和人体MRI中的使用效率.Due to the detection sensitivity provided by the high nuclear spin polarization,hyperpolarized ^(129)Xe has been employed in animal and human magnetic resonance imaging(MRI).However,during the accumulation-thawing process of hyperpolarized ^(129)Xe,multiple factors lead to the relaxation of spin polarization and would hinder the wider application of ^(129)Xe.In this research,the spin relaxation mechanism of hyperpolarized^(129)Xe during the accumulation-thawing process is investigated by both theoretical model analysis and experimental measurements.Meanwhile,the stability of the homebuilt device for the accumulation-thawing is measured.Our results demonstrate that the thawing mode and the cold trap material significantly affect the polarization loss;the automatic device is very stable during long-term operation and shows a high degree of automation,resulting in a polarization recovery ratio of 85.6%±4.7%.This research greatly helps to improve the efficiency of hyperpolarized^(129)Xe in animal and human MRI.

关 键 词：磁共振成像 超极化^(129)Xe气体 自动收集-升华装置 极化度恢复率 

分 类 号：O482.53[理学—固体物理]