分子影像新技术——氘代谢波谱及成像的综述与展望  

Review of a New Molecular Imaging Method——Deuterium Metabolic Spectroscopy and Imaging

作　　者：张怡 楼飞洋 方可 陈高 张孝通[4,1,2] ZHANG Yi;LOU Fei-yang;FANG Ke;CHEN Gao;ZHANG Xiao-tong(Department of Neurosurgery at the Second Affiliated Hospital of Zhejiang University School of Medicine,Zhejiang University,Hangzhou 310009,China;Interdisciplinary Institute of Neuroscience and Technology,Zhejiang University,Hangzhou 310020,China;Bruker(Beijing)Scientific Technology Co.Ltd.,Beijing 100081,China;College of Electrical Engineering,Zhejiang University,Hangzhou 310027,China)

机构地区：[1]浙江大学医学院附属第二医院神经外科,浙江大学,浙江杭州310009 [2]浙江大学系统神经与认知科学研究所,浙江杭州310020 [3]布鲁克(北京)科技有限公司,北京100081 [4]浙江大学电气工程学院,浙江杭州310027

出　　处：《波谱学杂志》2022年第3期356-365,共10页Chinese Journal of Magnetic Resonance

基　　金：国家重点研发计划项目(2018YFA0701400);国家自然科学基金资助项目(81701774,61771423)。

摘　　要：目前常用的分子影像技术主要有正电子发射型断层显像(PET)、质子磁共振波谱(^(1)H MRS)及成像(^(1)H MRSI)、化学交换饱和转移(CEST)、超极化^(13)C MRSI等.近4年来,氘代谢波谱(DMS)及成像(DMI)作为一种新兴的分子影像技术获得了越来越多的关注,其通过采集注射或口服氘代葡萄糖后的目标组织与正常组织间氘代谢产物的磁共振信号进行组织区分.相比于其他分子影像方法,该影像技术具有无辐射、稳定性好、扫描操作相对简单等优点.本文综述了近年来DMS/DMI技术的研究进展及其意义,归纳总结了其临床应用价值,并对该技术未来的发展和改进方向,以及应用前景进行了展望.Commonly used molecular imaging methods include positron emission tomography(PET),hydrogen magnetic resonance spectroscopy(^(1)H MRS)and imaging(^(1)H MRSI),chemical exchange saturation transfer(CEST),and hyperpolarized ^(13)C MRSI.As a cutting-edge molecular imaging method,deuterium metabolic spectroscopy(DMS)and imaging(DMI)has been recently developed and it distinguishes different tissues according to their specific glycometabolism.Compared with other molecular imaging methods,this promising technique has apparent advantages such as no radioactivity,good stability,and easy to maneuver.In this article,we review the progress of DMS/DMI and discuss its significance,future development,and potential clinical applications.

关 键 词：磁共振 代谢成像 葡萄糖 氘 肿瘤 

分 类 号：O482.53[理学—固体物理]