熊果酸研究热点与前沿的文献计量学分析  

Bibliometric analysis for research hotspot and frontier of ursolic acid

作　　者：赵俊[1] 张小蕾[1] 倪倍倍[1] 杨雪[1] 王凯[1] 张传洲[1] 刘广伟[2] ZHAO Jun;ZHANG Xiaolei;NI Beibei;YANG Xue;WANG Kai;ZHANG Chuanzhou;LIU Guangwei(Dept.of Pharmacy,the Affiliated Hospital of Qingdao University,Shandong Qingdao 266003,China;Dept.of Gastrointestinal Surgery,the Affiliated Hospital of Qingdao University,Shandong Qingdao 266003,China)

机构地区：[1]青岛大学附属医院药学部,山东青岛266003 [2]青岛大学附属医院胃肠外科,山东青岛266003

出　　处：《中国药房》2022年第17期2102-2107,共6页China Pharmacy

基　　金：山东省自然科学基金项目(No.ZR2021QH205,No.ZR2019PF017);山东省中医药科技项目(No.2021M171)。

摘　　要：目的探讨近20年熊果酸的研究热点与前沿,为该领域的研究者提供参考。方法搜集Web of Science数据库中与熊果酸的相关研究文献,检索时限设定为2002年1月1日至2021年12月31日,采用科学计量学软件Cite Space对文献中涉及的国家或地区、研究机构、作者、期刊和关键词等进行可视化分析,获取熊果酸的时空分布、研究前沿,通过分析关键词共现、关键词突现、关键词聚类等进一步分析熊果酸的研究现状和发展前沿。结果与结论最终纳入有效文献3528篇,发文量前3位的国家为中国、印度和美国;发文机构分析显示,中国科学院、卡拉奇大学、中国医科大学为发文量排名前3位的研究机构;发文期刊分析显示,Molecules(127篇)、Journal of Ethnopharmacology(90篇)、Journal of Agricultural and Food Chemistry(75篇)是研究发文量较高的3个期刊;关键词分析显示,熊果酸的抗肿瘤活性、抗氧化活性、抗菌活性、抗炎活性等药理作用一直是研究的重点,熊果酸诱导细胞凋亡、氧化应激、自噬等作用机制以及熊果酸纳米颗粒等药物输送方式的研究是未来一段时间的研究方向。OBJECTIVE To explore the research hotspots and development frontiers of ursolic acid in recent 20 years,and to provide reference for researchers in this field.METHODS Research literatures related to ursolic acid in Web of Science from Jan.,1,2002 to Dec.31,2021 were collected,and visualization analysis was performed on countries or regions,research institutions,authors,journals and keywords involved in the literatures using CiteSpace software,to obtain the spatial and temporal distribution of ursolic acid and research frontiers.The research status and development frontier of ursolic acid were further analyzed by analyzing keywords co-occurrence,keyword emergence,keyword clustering,etc.RESULTS&CONCLUSIONS Totally 3528 valid papers were included in this study,and the top three countries were China,India and the United States.Analysis of publishing institutions showed that Chinese Academy of Sciences,Univisity of Karachi and China Medical University were the top 3 research institutions in the list of publication amount.Analysis of published journals showed that Molecules(127 articles),Journal of Ethnopharmacology(90 articles),Journal of Agricultural and Food Chemistry(75 articles)had high number of literatures on ursolic acid.The analysis of keyword analysis showed that pharmacological effects,such as antitumor activity of ursolic acid,antioxidant activity,antibacterial activity and anti-inflammatory activity,are always the focus of the research;the mechanism ursolic acid induced apoptosis,oxidative stress and autophagy,the research on ursolic acid signaling pathway,drug delivery of ursolic acid nanoparticles were the research direction in the future.

关 键 词：熊果酸 文献计量学 研究热点 研究前沿 抗肿瘤活性 抗氧化活性 抗炎活性 抗菌活性 

分 类 号：R932[医药卫生—生药学]