5-HTR1A基因C-1019G多态性与抗抑郁药物疗效相关性的Meta分析  

Association of 5-HTR1A gene C-1019G polymorphism with antidepressant efficacy:a meta-analysis

作　　者：蔡文文 孙秀丽 崔健 李秀英 桂思兰 张俊青 CAI Wenwen;SUN Xiuli;CUI Jian;LI Xiuying;GUI Silan;ZHANG Junqing(Dept.of Pharmacy,Shangdong Daizhuang Hospital,Shandong Jining 272000,China;Dept.Four of Psychiatry,Shangdong Daizhuang Hospital,Shandong Jining 272000,China;Dept.One of Psychiatry,Shangdong Daizhuang Hospital,Shandong Jining 272000,China)

机构地区：[1]山东省戴庄医院药学部,山东济宁272000 [2]山东省戴庄医院精神四科,山东济宁272000 [3]山东省戴庄医院精神一科,山东济宁272000

出　　处：《中国药房》2022年第17期2142-2146,2156,共6页China Pharmacy

基　　金：国家自然科学基金资助项目(No.82071531);济宁市重点研发计划(软科学项目)(No.2021YXNS096)。

摘　　要：目的评价5-HTR1A基因C-1019G多态性与抗抑郁药物疗效的相关性。方法计算机检索PubMed、Embase、Cochrane图书馆、中国知网、万方数据、中国生物医学文献数据库和维普网,检索5-HTR1A基因C-1019G多态性与抗抑郁药物疗效相关性的国内外文献,检索时限均为建库起至2022年2月。根据药物应答结局指标的不同,采用Stata14.0和RevMan 5.4软件分别对有效组和缓解组进行Meta分析。结果共纳入18篇文献。合并结果显示,在有效组的隐性基因模型中,亚洲人群5-HTR1A基因C-1019G多态性与抗抑郁药物疗效有相关性(GG vs.CG+CC,OR=0.751,95%CI为0.585~0.964,P=0.024),中国地区患者5-HTR1A基因C-1019G多态性与抗抑郁药物疗效有相关性(GG vs.CG+CC,OR=0.677,95%CI为0.508~0.901,P=0.007);在缓解组中,5-HTR1A基因C-1019G多态性与抗抑郁药物疗效无相关性(P>0.05)。结论在有效组中,亚洲人群和中国地区患者5-HTR1A基因C-1019G多态性与抗抑郁药物疗效有相关性;而在缓解组中,尚不能证明该多态性与抗抑郁药物疗效有关。OBJECTIVE To evaluate the correlation between 5-HTR1A gene C-1019G polymorphism and the efficacy of antidepressants.METHODS PubMed,Embase,Cochrane Library,CNKI,Wanfang database,CBM and VIP database were searched for domestic and foreign literatures on the correlation between 5-HTR1A gene C-1019G polymorphism and antidepressant efficacy.The retrieval time limit was from the inception to February 2022.According to different outcome measures of drug response,Stata 14.0 and RevMan 5.4 software were used for meta-analysis of efficacy group and remission group,respectively.RESULTS A total of 18 literature were included.The combined results showed that among recessive gene model in valid group,the correlation of 5-HTR1A gene C-1019G polymorphism with the efficacy of antidepressants had statistically significance in Asian population(GG vs.CG+CC,OR=0.751,95%CI=0.585-0.964,P=0.024).There was statistical significance in the correlation of5-HTR1A gene C-1019G polymorphism and the efficacy of antidepressants in China(GG vs.CG+CC,OR=0.677,95%CI=0.508-0.901,P=0.007).There was no statistical significance in the correlation of 5-HTR1A gene C-1019G polymorphism and the efficacy of antidepressants in remission group(P>0.05).CONCLUSIONS In the effective group,5-HTR1A gene C-1019G polymorphism is correlated with the efficacy of antidepressants in the Asian population and the Chinese population;while in the remission group,it is not proved that this polymorphism is correlated with the efficacy of antidepressants.

关 键 词：抗抑郁药物 5-HTR1A基因 C-1019G多态性 疗效 META分析 

分 类 号：R971.43[医药卫生—药品] R749.05[医药卫生—药学]