奎屯地区337例哈萨克族和1000例汉族妇女宫颈人乳头状瘤病毒感染状况研究  

Study on the Status of Cervical Human Papillomavirus Infection among 337 Kazak and 1000 Han Women in Kui⁃tun Area

作　　者：吕新玲 鲁谨[2] 陈慧芸 周志梅 郑敏 LÜXin-ling;LU Jin;CHEN Hui-yun(Department of Pathology,Kuitun Hospital,Ili Kazakh Autonomous Prefecture,Xinjiang,833200,China)

机构地区：[1]新疆伊犁哈萨克自治州奎屯医院病理科,新疆奎屯833200 [2]新疆石河子大学一附院妇科,新疆石河子832003 [3]新疆伊犁哈萨克自治州奎屯医院妇科,新疆奎屯833200

出　　处：《黑龙江医学》2022年第15期1873-1876,共4页Heilongjiang Medical Journal

基　　金：伊犁哈萨克自治州科技计划项目伊州科字[2020]4号(YZ2020YD004)

摘　　要：目的:探讨、分析新疆奎屯地区哈萨克族和汉族妇女宫颈人乳头状瘤病毒(HPV)感染状况、型别分布,为本地区宫颈癌防治提供科学依据。方法:选择自2012年3月—2018年6月自愿接受宫颈HPV感染筛查的、有性生活的哈萨克族妇女(337例)和汉族妇女(1000例)行宫颈HPV检测。结果:哈萨克族总体感染率为27.89%,汉族为25.1%,两个民族比较,差异无统计学意义(P>0.05)。哈萨克族单一基因型别感染率为65.96%,最常见的感染亚型依次为52、16、56、81、18、53型;汉族为68.53%,最常见的感染亚型依次为52、16、42、51、53、56型;两个民族多重感染大多以HPV 52、16型与其他亚型混合感染;哈萨克族高危型HPV感染频率依次为HPV52、16、53、51和39/56、18,汉族高危型HPV感染频率依次为HPV 52、16、51、53、58和56/68。哈萨克族妇女HR-HPV感染与年龄相关,在<35岁年龄组明显高于其他年龄组,汉族妇女不同年龄组高危型HPV感染率差异无统计学意义(P>0.05),但在45~50岁、>50岁年龄组感染率较高,哈萨克族妇女高危型HPV感染率在<35岁组、35~40岁组高于汉族,差异有统计学意义(χ^(2)=13.51、4.00,P<0.05)。结论:两个民族感染率无差别,本地区哈萨克族、汉族妇女感染型别均以HPV52、16型为主,在本地区应加强对<35岁及35~40岁年龄组哈萨克族人群和45-50岁及>50岁年龄组汉族人群监测、健康宣教。Objective:To discuss and analyze the cervical human papillomavirus(HPV)infection status and type distribution of Kazak and Han women in Kuitun area of Xinjiang,and provide scientific basis for the prevention and treatment of cervical cancer in this area.Methods:From March 2012 to June 2018,sexually active Kazakh women(337 cases)and Han women(1000 cases)who voluntarily received cervical HPV infection screening were selected for cervical HPV testing.Results:The overall infection rate of Kazakhs was 27.89%,and that of Han was 25.1%.There was no significant difference between the two nationalities(P>0.05).The infection rate of a single genotype in Kazakhs was 65.96%,and the most common subtypes were type 52,16,56,81,18,and 53.The infection rate of Han nationality was 68.53%,and the most common subtypes were 52,16,42,51,53,and 56.Most of the multiple infections of the two nationalities were mixed infection of HPV 52,16 and other subtypes.The infection fre⁃quencies of high-risk HPV in Kazakhs were HPV52,16,53,51 and 39/56,18,and the infection frequencies of high-risk HPV in Han were HPV 52,16,51,53,58,and 56/68.HR-HPV infection in Kazakh women was related to age,and it was significantly higher in the<35-year-old age group than in other age groups.There was no statistically significant difference in the infection rate of high-risk HPV among different age groups among Han women(P>0.05).However,the infection rate was higher in the age group of 45-50 years old and>50 years old.The infection rate of high-risk HPV in Kazakh women was higher in the<35-year-old group and in the 35-40-year-old group than in the Han,the difference was statistically significant(χ2=13.51,4.00,P<0.05).Conclusion:There was no difference in the infection rate between the two ethnic groups.The infection types of Kazakh and Han women in this area were mainly HPV52 and 16.In this region,monitoring and health education should be strengthened for the Kazakh population in the age group of<35 and 35-40 and the Han population in the age group of 45-50 and

关 键 词：哈萨克族 汉族 宫颈人乳头状瘤病毒 基因分型 

分 类 号：R711.74[医药卫生—妇产科学]