IgA肾病扁桃体淋巴细胞亚群与患者蛋白尿的相关性分析  

Correlation Analysis Between Lymphocyte Subsets of Tonsil Tissues and Proteinuria in Patients with IgA Nephropathy

作　　者：徐艺[1] 胡豪飞 许日聪 刘洋[1] 卢玺峰 何永成[1,3] XU Yi;HU Haofei;XU Ricong(Department of Nephrology,the First Affiliated Hospital of Shenzhen University(Shenzhen Second People’s Hospital),Shenzhen,518035)

机构地区：[1]深圳大学第一附属医院(深圳市第二人民医院)肾内科,深圳518035 [2]深圳大学医学部生理系,深圳518060 [3]深圳恒生医院肾内科,深圳518102

出　　处：《中国中西医结合肾病杂志》2022年第6期499-502,共4页Chinese Journal of Integrated Traditional and Western Nephrology

基　　金：深圳市医学重点学科建设项目(No.SZXK009);深圳市医疗卫生三名工程项目(No.SZSM201512004);深圳市第二人民医院临床研究项目(No.20193357002)。

摘　　要：目的:观察IgA肾病患者扁桃体淋巴细胞亚群分布特点,探讨生发中心及滤泡间区淋巴细胞变化与蛋白尿的相关性。方法:IgA肾病行扁桃体切除术患者31例,采用免疫组化方法检测生发中心及滤泡间区的CD_(4)、CD_(19)、CD_(20)、CD_(21)及IgA1的标记细胞数,使用单因素分析、线性回归及曲线拟合对尿蛋白与淋巴细胞亚群进行分析。结果:24 h尿蛋白与生发中心的CD^(+)_(21)淋巴细胞计数呈显著正相关。生发中心CD^(+)_(21)淋巴细胞计数及滤泡间区CD^(+)_(19)淋巴细胞计数与尿蛋白水平正相关,生发中心CD^(+)_(19)淋巴细胞计数与24 h尿蛋白呈n形曲线关系。结论:IgA肾病患者扁桃体生发中心及滤泡间区的淋巴细胞分布与尿蛋白水平存在明显相关性,可能与IgA肾病的病情进展密切相关。Objective:To explore the correlation between the changes of lymphocytes in tonsil germinal center and interfollicular area and proteinuria in patients with IgA nephropathy.Methods:Thirty-one IgA nephropathy patients who underwent tonsillectomy were enrolled in this study.Immunohistochemical analysis was used to detect the number of CD_(4),CD_(19),CD_(20),CD_(21),and IgA1 labeled cells in the germinal center and interfollicular area.Linear regression and curve fitting were used to analyze the correlation between 24-hour urinary protein level and the distribution of lymphocyte subsets in tonsil tissue.Results:The correlation analysis showed that 24-hour urinary protein was significantly positively correlated with the CD^(+)_(21)lymphocytes of the tonsil germinal center.CD^(+)_(21)lymphocytes in the germinal center and CD^(+)_(19)lymphocytes in the interfollicular area were positively correlated with urinary protein levels.There was an n-shaped relationship between CD^(+)_(19)lymphocytes and 24-hour urine protein in the germinal center.Conclusion:There are significant correlations between lymphocyte subsets distribution in the germinal center and interfollicular area of the tonsil and the level of proteinuria in patients with IgA nephropathy,suggesting that may be closely related to the progression of IgA nephropathy.

关 键 词：IGA肾病 扁桃体淋巴细胞亚群 蛋白尿 生发中心 滤泡间区 

分 类 号：R692.31[医药卫生—泌尿科学]