脑苷肌肽联合认知功能训练对急性脑梗死患者认知功能的影响  

Effect of Cattle Encephalon Glycoside and Ignotin Combined with Cognitive Function Training on Cognitive Function of Patients with Acute Cerebral Infarction

作　　者：杨球 潘家兴[1] 陈旭[1] 陈薪旭 YANG Qiu;PAN Jiaxing;CHEN Xu;CHEN Xinxu(People′s Hospital of Wanning,Wanning,Hainan,China 571500;The First Affiliated Hospital of Hainan Medical University,Haikou,Hainan,China 570311)

机构地区：[1]海南省万宁市人民医院,海南万宁571500 [2]海南医学院第一附属医院,海南海口570311

出　　处：《中国药业》2022年第17期88-90,共3页China Pharmaceuticals

基　　金：海南省卫生计生行业科研项目[19A200152]。

摘　　要：目的 探讨脑苷肌肽联合认知功能训练对急性脑梗死患者认知功能的影响。方法 选取海南省万宁市人民医院2019年8月至2021年2月收治的急性脑梗死患者98例,采用随机抽签法分为观察组和对照组,各49例。两组患者均行常规治疗和认知功能训练,观察组患者联用脑苷肌肽,均连续治疗2周。结果 观察组总有效率为89.80%,显著高于对照组的73.47%(P <0.05)。治疗后,观察组患者的简易精神状态评价量表(MMSE)、蒙特利尔认知评估量表(MoCA)评分均显著高于对照组,美国国立卫生研究院卒中量表(NIHSS)评分显著低于对照组(P <0.05);观察组患者的生存质量评分均显著高于对照组(P <0.05);观察组患者的血清总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)水平均显著低于对照组,高密度脂蛋白胆固醇(HDL-C)水平显著高于对照组(P <0.05)。治疗期间,观察组与对照组的药品不良反应发生率无显著差异(16.33%比10.20%,P> 0.05)。结论 脑苷肌肽联合认知功能训练可改善急性脑梗死患者的认知功能、生存质量和血脂指标水平,且治疗安全性良好。Objective To investigate the effect of cattle encephalon glycoside and ignotin combined with cognitive function training on the cognitive function of patients with acute cerebral infarction.MethodsA total of 98 patients with acute cerebral infarction admitted to the People’s Hospital of Wanning from August 2019 to February 2021 were selected and divided into the observation group and the control group according to the random lottery method,with 49 cases in each group.The patients in both groups were treated with routine treatment and cognitive function training,on this basis,the patients in the observation group were treated with cattle encephalon glycoside and ignotin.Both groups were treated continuously for two weeks.ResultsThe total effective rate in the observation group was 89.80%,which was significantly higher than 73.47%in the control group (P<0.05).After treatment,the scores of the Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA) in the observation group were significantly higher than those in the control group,while the National Institutes of Health Stroke Scale (NIHSS) score in the observation group was significantly lower than that in the control group (P<0.05).The score of quality of life in the observation group was significantly higher than that in the control group (P<0.05).The levels of serum total cholesterol (TC),triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C) in the observation group were significantly lower than those in the control group,while the level of high-density lipoprotein cholesterol (HDL-C) in the observation group was significantly higher than that in the control group (P<0.05).During the treatment,the incidence of adverse drug reactions in the observation group was similar to that in the control group (16.33%vs.10.20%,P>0.05).ConclusionCattle encephalon glycoside and ignotin combined with cognitive function training can improve the cognitive function,quality of life and blood lipid index levels of patients with acute cerebral i

关 键 词：脑苷肌肽 急性脑梗死 认知功能训练 认知功能障碍 生活质量 血脂 

分 类 号：R969.4[医药卫生—药理学] R971[医药卫生—药学]