一氧化氮治疗肿瘤的研究进展  

Research progress of nitric oxide in the treatment of tumor

作　　者：王丽凯 田娅 吴惠霞 WANG Likai;TIAN Ya;WU Huixia(College of Chemistry and Materials Science,Shanghai Normal University,Shanghai 200234,China)

机构地区：[1]上海师范大学化学与材料科学学院,上海200234

出　　处：《上海师范大学学报（自然科学版）》2022年第4期443-451,共9页Journal of Shanghai Normal University(Natural Sciences)

基　　金：上海市自然科学基金(20ZR1441400)。

摘　　要：一氧化氮(NO)是一种半衰期很短的气体分子,对细胞膜具有高穿透性,能在人体内传递重要信息,并具有调节细胞的功能.NO气体分子既能维持正常细胞的生理功能和活性,又能选择性地快速耗尽肿瘤细胞的能量,诱导肿瘤细胞凋亡.研究表明:NO可以通过多种机制实现肿瘤治疗.已有一些NO供体药物表现出良好的抗肿瘤活性,精确控制NO在肿瘤部位的释放,可杀死肿瘤细胞.因此,NO气体疗法作为一种肿瘤治疗策略具有一定的应用前景.文章简述了NO的生理学特性和几种典型的NO供体,以及释放NO的生物材料在生物医学领域的应用进展.Nitric oxide(NO)is a ubiquitous gas molecule with a short half-life.It is highly permeable to cell membranes and can transmit important information and regulate cellular functions in the human body.NO molecules can not only maintain the physiological function and activity of normal cells,but also selectively and rapidly deplete the energy of tumor cells and induce their apoptosis.Studies have shown that NO may achieve tumor therapy through a variety of mechanisms.Some NO donor drugs have shown good anti-tumor activity and can be used to precisely control the release of NO at tumor sites and kill tumor cells.Therefore,NO gas therapy is a promising tumor treatment strategy.This review covers the physiological characteristics of NO,several typical NO donors,and the application progress of NO releasing biomaterials in biomedical field.

关 键 词：一氧化氮(NO) NO供体 肿瘤 气体治疗 生物材料 

分 类 号：O613.6[理学—无机化学]