p75神经营养因子受体在神经退行性疾病中的作用  

The role of p75 neurotrophin receptor in neurodegenerative diseases

作　　者：秦晓颖[1] 刘刚 廖红[1] QIN Xiao-ying;LIU Gang;LIAO Hong(New Drug Screening Center,Jiangsu Center for Pharmacodynamics Research and Evaluation,China Pharmaceutical University,Nanjing 210009,China)

机构地区：[1]中国药科大学新药筛选中心,江苏省药效研究与评价服务中心,江苏南京210009

出　　处：《中国药理学通报》2022年第9期1288-1292,共5页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 82073831)。

摘　　要：近年来,研究发现神经营养因子受体p75NTR在包括阿尔茨海默症(Alzheimer’s disease,AD)、帕金森病(Parkinson′s disease,PD)、亨廷顿病(Huntington′s disease,HD)、肌萎缩性侧索硬化(amyotrophic lateral sclerosis,ALS)、多发性硬化症(multiple sclerosis,MS)等神经退行性疾病的发生发展中起到关键调控作用。该文综述近年来p75NTR通过引起神经元凋亡,轴突变性等造成认知和记忆功能障碍的研究进展,探讨p75NTR作为潜在治疗靶点在神经退行性疾病治疗中的应用前景。Recently p75 neurotrophin receptor(p75NTR)has been found to play a critical role in the pathology of neurodegenerativel diseases including Alzheimer’s disease(AD),Parkinson’s disease(PD),Huntington’s disease(HD),amyotrophic lateral sclerosis(ALS)and multiple sclerosis(MS).This article reviews the research progress of p75NTR in regulating neuron apoptosis,axon degeneration and cognitive impairment,exploring the application of p75NTR as a potential therapeutic target for the treatment of neurodegenerative diseases.

关 键 词：P75神经营养因子受体 神经元凋亡 轴突变性 认知和记忆功能障碍 阿尔兹海默症 神经退行性疾病 

分 类 号：R322.81[医药卫生—人体解剖和组织胚胎学] R338.64[医药卫生—基础医学] R349.32R745.7