重度胆汁淤积症产妇早产儿脐血CC16及SP-A水平与肺损伤的关系探讨  

Correlation between the levels of CC16 and SP-A in cord blood and intrahepatic cholestasis of pregnancy-induced lung injury in premature infants

作　　者：袁莉 王丽雁 童学东 刘润宁[3] 孙玉姗 马倩 徐雅丽 YUAN Li;WANG Liyan;TONG Xuedong;LIU Running;SUN Yushan;MA Qian;XU Yali(Department of Pediatric Center,The third Affiliated Hospital of Chongqing Medical Universtiy,Chongqing 401120,China;Department of Clinical Laboratory,The Third Affiliated Hospital of Chongqing Medical Universtiy,Chongqing 401120,China;Department of Child Healthcare,The Fifth People’s Hospital of Chongqing,Chongqing 400014,China)

机构地区：[1]重庆医科大学附属第三医院儿科中心,重庆401120 [2]重庆医科大学附属第三医院检验科,重庆401120 [3]重庆市第五人民医院儿童保健科,重庆400014

出　　处：《医药前沿》2022年第21期27-29,共3页Journal of Frontiers of Medicine

基　　金：重庆市区科卫联合医学科研项目(2020-07)。

摘　　要：目的:探讨妊娠期重度胆汁淤积症(ICP)产妇早产儿脐血血清中Clara细胞分泌蛋白(CC16)及肺表面活性物质蛋白A(SP-A)水平与肺损伤的关系。方法:选取2019年9月—2021年5月重庆医科大学附属第三医院妇产科剖宫产娩出的102例34~37周早产儿脐血标本。其中,产妇孕期合并重度ICP的标本设为ICP组(n=56),产妇孕期无合并症的标本设为对照组(n=46)。采用酶联免疫吸附试验(ELISA)方法检测脐血血清中C C16及SP-A水平。比较两组患儿肺损伤发生情况与脐血血清中C C16和SP-A的浓度关系。结果:ICP组肺损伤发生率(62.5%)高于对照组(39.1%),差异有统计学意义(P<0.05);ICP组脐血血清C C16水平(46.86±2.19)n g/m L及SP-A水平(95.35±3.26)pg/mL均低于对照组CC16水平(70.38±2.30)ng/mL及SP-A水平(153.9±8.10)pg/mL,差异有统计学意义(P<0.05)。结论:脐血CC16及SP-A水平可作为早期预测及诊断重度ICP产妇早产儿肺损伤的指标。Objective To investigate the correlation between the levels of Clara cell secretory protein(CC16)and pulmonary surfactant protein A(SP-A)in cord blood serum and severe ICP-induced lung injury in preterm infants.Methods Totally 102 cord blood samples of 34~37 weeks premature infants were collected from the Third Affiliated Hospital of Chongqing Medical University from September 2019 to May 2021.They were divided into two groups:ICP group(56 cases)and control group(46 cases).The levels of CC16 and SP-A in cord blood serum were detected by enzyme-linked immunosorbent assay(ELISA).The incidence of lung injury and the concentrations of CCSP and SP-A in cord blood serum were compared between the two groups.Results The incidence of lung injury in group ICP was significantly higher than that in control group,and the levels of CC16 and SP-A in cord blood of group ICP were lower than those of control group(P<0.05).Conclusion The detection of CC16 and SP-A levels in cord blood can be used as a reference for early prediction and diagnosis of lung injury in severe ICP preterm infants.

关 键 词：早产儿 妊娠期胆汁淤积症 肺损伤 CLARA细胞分泌蛋白 肺表面活性物质蛋白A 

分 类 号：R722.6[医药卫生—儿科]