依帕司他与α硫辛酸联合治疗糖尿病周围神经病变的疗效及作用机制研究  

The Efficacy and Mechanism of Epalrestat Combined with Alpha Lipoic Acid in the Treatment of Diabetic Peripheral Neuropathy

作　　者：张松涛 王萍 刘晴芽 郭慧 ZHANG Songtao;WANG Ping;LIU Qingya;GUO Hui(Department of Endocrinology,Gaochun People's Hospital,Nanjing,Jiangsu Province,211300 China;Department of Neurology,Gaochun People's Hospital,Nanjing,Jiangsu Province,211300 China)

机构地区：[1]南京市高淳人民医院内分泌科,江苏南京211300 [2]南京市高淳人民医院神经内科,江苏南京211300

出　　处：《糖尿病新世界》2022年第14期156-159,共4页Diabetes New World Magazine

摘　　要：目的 观察分析依帕司他与α硫辛酸联合治疗糖尿病周围神经病变(diabetic peripheral neuropathy,DPN)的临床效果,并探索其作用机制。方法 采用随机数字表法将2018年5月—2021年11月南京市高淳人民医院内分泌科收治的496例DPN患者分为两组。所有患者先控制血糖,对照组(248例)用α硫辛酸治疗,观察组(248例)加用依帕司他治疗。观察分析用药前后神经传导速度和炎症因子指标改变情况,评估临床疗效。结果 治疗后,两组腓总神经、正中神经的感觉神经传导速度(SCV)、运动神经传导速度(MCV)增加,且与对照组比较,观察组腓总神经、正中神经的SCV、MCV增加明显,差异有统计学意义(P<0.05)。治疗后复查,两组患者的肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)和白介素-8(IL-8)指标下降,且观察组的TNF-α、IL-6和IL-8较对照组降低明显,差异有统计学意义(P<0.05)。观察组临床疗效优于对照组(95.97%vs 85.89%),差异有统计学意义(P<0.05)。结论 临床采用依帕司他联合α硫辛酸治疗DPN能加快神经功能传导速度,抑制炎症反应,疗效突出。Objective To observe and analyze the clinical effect of epalrestat combined with α lipoic acid in the treatment of diabetic peripheral neuropathy(DPN),and to explore its mechanism.Methods A total of 496 DPN patients admitted to Department of Endocrinology,Gaochun People’s Hospital,Nanjing from May 2018 to November 2021 were divided into two groups by random number table method.All patients were treated with blood glucose control first,while the control group(248 cases) was treated with α lipoic acid,and the observation group(248 cases)was treated with epalrestat.The changes of nerve conduction velocity and inflammatory factors before and after medication were observed and analyzed to evaluate the clinical efficacy.Results After treatment,the sensory nerve conduction velocity(SCV) and motor nerve conduction velocity(MCV) of the common peroneal nerve and median nerve in the two groups increased,and compared with the control group,the SCV and MCV of the common peroneal nerve and median nerve in the observation group increased significantly,and the difference was statistically significant(P<0.05).After treatment,tumor necrosis factor-α(TNF-α),interleukin-6(IL-6) and interleukin-8(IL-8) in two groups decreased,and TNF-α,IL-6 and IL-8 in observation group decreased significantly compared with control group,the difference was statistically significant(P<0.05).The clinical efficacy of observation group was better than control group(95.97% vs 85.89%),and the difference was statistically significant(P<0.05).Conclusion The clinical use of epalrestat combined with α lipoic acid in the treatment of DPN can accelerate the conduction velocity of nerve function,inhibit the inflammatory response,and has outstanding curative effect.

关 键 词：依帕司他 Α硫辛酸 糖尿病周围神经病变 神经传导速度 

分 类 号：R587.2[医药卫生—内分泌]