联用利拉鲁肽、短期胰岛素强化治疗对初诊肥胖2型糖尿病患者血糖水平、炎性因子的影响  

Effects of Combined Use of Liraglutide and Short-term Intensive Insulin Therapy on Blood Glucose Levels and Inflammatory Factors in newly Diagnosed Obese Patients with Type 2 Diabetes Mellitus

作　　者：仲丽娟[1] 金辉[1] 贲曙萍[1] ZHONG Lijuan;JIN Hui;BEN Shuping(Department of Endocrinology,People's Hospital of Dongtai City,Dongtai,Jiangsu Province,224200 China)

机构地区：[1]江苏省东台市人民医院内分泌科,江苏东台224200

出　　处：《糖尿病新世界》2022年第13期19-22,27,共5页Diabetes New World Magazine

摘　　要：目的 分析利拉鲁肽+短期胰岛素强化治疗在初诊肥胖2型糖尿病中的作用。方法 纳入江苏省东台市人民医院于2019年12月—2021年12月诊治的初诊肥胖2型糖尿病患者60例为研究对象,经抽签法分组,对照组30例予以短期胰岛素强化治疗,观察组30例在对照组基础上给予利拉鲁肽联合治疗。对比两组血糖水平、炎性因子、血脂代谢和氧化应激水平。结果 用药前,两组各项指标比较,差异无统计学意义(P>0.05);用药后,观察组血糖指标、体质量指数、炎性因子、血脂指标和氧化应激指标水平更低,载脂蛋白A1、总抗氧化能力和谷胱甘肽过氧化物酶水平更高,与对照组比较差异有统计学意义(P<0.05)。结论 对初诊肥胖2型糖尿病患者实施利拉鲁肽联合短期胰岛素强化治疗方案,可有效控制血糖水平和体质量,改善机体炎症状态、血脂代谢,也可抑制氧化应激反应。Objective To analyze the effect of liraglutide+short-term intensive insulin therapy on newly diagnosed obese type 2 diabetes mellitus.Methods A total of 60 newly diagnosed obese patients with type 2 diabetes who were diagnosed and treated in Dongtai People’s Hospital of Jiangsu Province from December 2019 to December 2021 were included as the research objects.Grouped by lottery,30 cases in the control group,received short-term intensive insulin therapy,and 30 cases in the observation group were given combined treatment with liraglutide on the basis of the control group.The levels of blood glucose,inflammatory factors,lipid metabolism and oxidative stress were compared between the two groups.Results Before treatment,there was no statistically significant difference in each index between the two groups(P>0.05).After medication,compared with the control group,the observation group had lower levels of blood glucose indexes,body mass index,inflammatory factors,blood lipid indexes and oxidative stress indexes,and higher levels of apolipoprotein A1,total antioxidant capacity and glutathione peroxidase,the difference was statistically significant(P<0.05).Conclusion Liraglutide combined with short-term intensive insulin therapy for newly diagnosed obese patients with type 2 diabetes can effectively control blood glucose level and body weight,improve the body’s inflammatory state and blood lipid metabolism,and also inhibit oxidative stress response.

关 键 词：利拉鲁肽 短期胰岛素 肥胖 2型糖尿病 

分 类 号：R587.1[医药卫生—内分泌]