甘精胰岛素联合瑞格列奈对2型糖尿病的临床疗效分析  

Clinical Efficacy Analysis of Insulin Glargine Combined with Repaglinide on Type 2 Diabetes Mellitus

作　　者：刘正丽[1] 王艳梅[2] 孙志强[3] LIU Zhengli;WANG Yanmei;SUN Zhiqiang(Emergency Department,Qianwei Hospital,Changchun,Jilin Province,130000 China;Department of Radiotherapy,Jilin Province Cancer Hospital,Changchun,Jilin Province,130000 China;Interventional Department,Jilin Province Cancer Hospital,Changchun,Jilin Province,130000 China)

机构地区：[1]吉林省前卫医院急诊科,吉林长春130000 [2]吉林省肿瘤医院放射治疗科,吉林长春130000 [3]吉林省肿瘤医院介入科,吉林长春130000

出　　处：《糖尿病新世界》2022年第13期78-80,88,共4页Diabetes New World Magazine

摘　　要：目的 探讨甘精胰岛素联合瑞格列奈对2型糖尿病的治疗效果。方法 随机选取2019年2月—2020年12月就诊于吉林省前卫医院的94例2型糖尿病患者作为研究对象,按照随机数法将其分为观察组和对照组,每组47例。对照组患者的治疗方案为单独应用甘精胰岛,观察组的治疗方案为联合应用甘精胰岛素和瑞格列奈。对两组患者的血糖变化、治疗效果及安全性进行观察和分析。结果 治疗后,观察组空腹血糖为(3.33±0.84)mmol/L,低于对照组(7.06±0.75)mmol/L,差异有统计学意义(t=22.708,P<0.05);观察组餐后2 h血糖为(7.08±1.48)mmol/L,低于对照组(8.22±1.63)mmol/L,差异有统计学意义(t=3.549,P<0.05);观察组不良反应发生率为2.12%,低于对照组的14.89%,差异有统计学意义(P<0.05);观察组总有效率为97.87%,高于对照组的82.98%,差异有统计学意义(P<0.05)。结论 在2型糖尿病的治疗中,甘精胰岛素联合瑞格列奈的治疗方案可有效提升患者的治疗有效率,且安全性较高,值得临床应用和推广。Objective To investigate the therapeutic effect of insulin glargine combined with repaglinide on type 2 diabetes mellitus.Methods 94 cases patients with type 2 diabetes who visited Qianwei Hospital of Jilin Province from February 2019 to December 2020 were randomly selected as the subjects of this study.They were divided into observation group and control group according to random number method,and each group included 47 cases.The control group was treated with islet glargine alone,and the observation group was treated with the combination of insulin glargine and repaglinide.The blood glucose changes,treatment effects and safety of the two groups of patients were observed and analyzed.Results After treatment,the fasting blood glucose of the observation group was(3.33±0.84) mmol/L,which was lower than that of the control group(7.06±0.75) mmol/L,and the difference was statistically significant(t=22.708,P<0.05);the 2 h postprandial blood glucose of the observation group was(7.08±1.48) mmol/L,which was lower than that of the control group(8.22±1.63) mmol/L,and the difference was statistically significant(t=3.549,P<0.05);the incidence of adverse reactions in the observation group was 2.12%,which was lower than14.89% in the control group,and the difference was statistically significant(P<0.05);the total effective rate in the observation group was 97.87%,which was higher than 82.98% in the control group,and the difference was statistically significant(P<0.05).Conclusion In the treatment of type 2 diabetes,the treatment plan of insulin glargine combined with repaglinide can effectively improve the treatment efficiency of patients with high safety,which is worthy of clinical application and promotion.

关 键 词：甘精胰岛素 瑞格列奈 2型糖尿病 

分 类 号：R587.1[医药卫生—内分泌]